主要成就
代表性SCI论文 （*通讯作者）
1.Xiong K., Jin R., Hu K. and Ding D. 1990 "Synthesis and cloning of the human growth hormone releasing factor gene" Chinese Journal of Biotechnology (English Version) 6, 243-250
2.Hu K. 2000 “Wechselwirkung beider Startstellen der Transkription von mutierten zirkulären Viroidmolekülen” Dissertation, Heinrich-Heine-Universität Düsseldorf, Germany 1-120 (in German)
3.Fels A., Hu K. and Riesner D. 2001 "Transcription of potato spindle tuber viroid by RNA polymerase II starts predominatly at two specific sites" Nucleic Acids Research 29(22), 4589-4597
4.Hu K., Beck J. and Nassal M. 2004 "SELEX-derived aptamers of the duck hepatitis B virus RNA encapsidation signal distinguish critical and non-critical residues for productive initiation of reverse transcription" Nucleic Acids Research 32(14), 4377-4389
5.Hu K. et al. 2005 "Characterization of the human zinc finger protein 267 promoter: Essential role of nuclear factor Y" Biochimica et BiophysicaActa 1729, 14-23
6.Schnabl B., Hu K., Mühlbauer M. and Schoelmerich J. 2005 "Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10" Biochemical and Biophysical Research Communications 335, 87-96
7.Nadine K., Oliver B., Ashermann K., Hu K. and Riesner D. 2006 “Transcription of potato spindle tuber viroid by RNA polymerase II starts in the left terminal loop” Virology 347(2), 392-404
8.Hu K et al. 2007 “Chemically defined medium determines the differential potency of renal stem cells” Biotechnology Journal 2(8), 992-995
9.Heber S., Denk L., Hu K.*. 2007 “Modulating the development of renal tubules growing in serum-free culture medium at an artificial interstitium” Tissue Engineering 13(2), 281-292
10.Minuth WW., Denk L. and Hu K.* 2007 “The role of polyester interstitium and aldosterone during structural development of renal tubules in serum-free medium” Biomaterials 28(30), 4418-4428
11.Minuth WW, Hu K* 2007 “Kontrolliertes Environment für Stammzellen – Generierung renaler Tubuli in chemisch definiertem Kulturmedium“ Bioforum 4:28-29
12.Minuth WW, Denk L and Hu K.* 2007 “Kontrolliertes Environment für die Entwicklung von Stammzellen zu renalen Tubuli“ Regenerativ Medizin 2(1):22-27
13.Minuth WW, Denk L, Hu K. et al. 2007 “The tubulogenic effect of aldosterone is attributed to intact binding and intracellular response of the mineralocorticoid receptor” Central European Journal of Biology 2(3), 307-325
14.Ke B. and Hu K*. 2007 "Environmental pollution and skin diseases" Medical Recapitulate 13(18), 1377-1379
15.Hu K.* and Yao Y. 2008 “Advances in application of three-dimensional cell culture” Journal of Medical Molecular Biology 5(2):185-188
16.Feng H and Hu K*. 2008 "Aptamers against viral hepatitis from rational design to practical application" Virologica Sinica 23(5):315-320
17.Feng H and Hu K*. 2009 "Structural Characteristics and Molecular Mechanism of Hepatitis B Virus Reverse Transcriptase" Virologica Sinica 24(6):509-517
18.Hu K*. 2010 "From Minu3D cultural system to aldosterone-induced tubulogenesis" Journal of Clinical Rehabilitative Tissue Engineering Research 14(2):365-369
19.Chen P, Rayner S, and Hu K*. 2011 "Advances of bioinformatics tools applied in virus epitopes prediction" Virologica Sinica 26(1):1-7
20.Feng H , Beck J, Nassal M and Hu K*. 2011 “A SELEX-Screened aptamer of human hepatitis B virus RNA encapsidation signal suppresses viral replicationi“ Plos One 6(11):e27862
21.Zhao Z, Hong W, Zeng Z, Wu Y, Hu K et al. 2012 "Mucroporin-M1 inhibits hepatitis B virus replication by activating the MAPK pathawy and down-regulating HNF4α in vitro and in vivo" J Biol Chem.287(36):30181-90.
22.Wang W, Peng H, Li J, Zhao X, Zhao F, Hu K. * 2013 "Controllable inhibition of hepatitis B virus replication by a DR1-targeting short hairpin RNA (shRNA) expressed from a DOX-inducible lentiviral vector." Virus Genes 46(3):393-403.
23.Feng H, Chen P, Zhao F , Nassal M, Hu K* 2013 “Evidence for Multiple Distinct Interactions between Hepatitis B Virus P Protein and Its Cognate RNA Encapsidation Signal during Initiation of Reverse Transcription. Plos One 8:e72798.
24.Chen P, Yun G, Na H, Wei F, Li J, Zhao F, Rayner S*, Hu K. * 2013 "Computational evolutionary analysis of the overlapped surface (S) and polymerase (P) region in hepatitis B virus indicates the spacer domain in P is crucial for survival." PLoS One 8(4):e60098.
25.Pan X, Li XJ, Liu XJ, Tian XH, Hu KH.et al. 2013 Later Passage Neural Progenitor Cells from Neonatal Brain Are More Permissive for Human Cytomegalovirus Infection. Journal of Virology 87(20):10968-10979.
26.Tian X, Zhao F, Cheng Z, Zhou M, Zhi X, Li J, Hu K*. 2013 GCN5 acetyltransferase inhibits PGC1α-induced hepatitis B virus biosynthesis. Virologica Sinica 28(4):216-22.
27.Zhou M, Zhao F, Li J, Cheng Z, Tian X, Huang Y, Zhi X and Hu K*. 2014 "Long-term maintenance of human fetal hepatocytes and prolonged susceptibility to HBV infection by co-culture with nonparenchymal cells" J Virol Methods 195:185-193
28.Zhou M, Huang Y, Cheng Z, Zhao F, Li J, Zhi X, Tian X, Sun W, Hu K* 2014 Revival, characterization, and hepatitis B virus infection of cryopreserved human fetal hepatocytes. J Virol Methods 207:29-37
29.Tian Xiaohui, Zhao Fei, Sun Weihua, Zhi Xiaoguang, Hu Kanghong* 2014 CRTC2 enhances HBV transcription and replication by inducing PGC1alpha expression. Virology Journal 11:30, doi: 10.1186/1743-422X-11-30.
30.Cheng Z, Sun G, Guo W, Huang Y, Sun W, Zhao F, Hu K* 2015 Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines. Virologica Sinica 30(4):261-268.
31.Cheng ZK, Zhi XG, Sun G, Guo W, Zhao F, Hu KH* 2016 Sodium selenite suppresses hepatitis B virus transcription and replication in human hepatoma cell lines. J Med Virol. 88(4):653-663
32.Danzhen Pan , Yong Lin, Weimin Wu, Jingjiao Song, Ejuan Zhang, Chunchen Wu, Xinwen Chen, Kanghong Hu et al.2015 “Persistence of the Recombinant Genomes of Woodchuck Hepatitis Virus in the Mouse Model” PLoSOne 10(5):e0125658
33.Peng Ke, Honghao Sun, Mingxing Liu, Zhengding Su, Kanghong Hu et al. 2016 “Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide” IET Nanobiotechnol., 10( 1): 8-12
34. Xiaoli Ye, Ming Zhou,Yonggang He,Yanmin Wan, WeiyaBai, Shuai Tao, YanqinRen, Xinxin Zhang, JianqingXu, Jing Liu, Junqi Zhang, Kanghong Hu* et al. 2016” Efficient Inhibition of Hepatitis B Virus Infection by a preS1-binding Peptide” Scientific Reports 6:29391DOI: 10.1038/srep29391
35.HU Kanghong et al. 2017 “KNK437 Inhibits Replication and Transcription of the Hepatitis B Virus” Chinese Journal of Virology (English Version) 01:24-35
36.Mengying Ji and Kanghong Hu* 2017 "Recent advances in the study of hepatitis B virus covalently closed circular DNA" Virologica Sinica 32(6):454-464
37.Yao Chengguang, Xi Caili, Hu Kanghong et al. 2018 "Inhibition of enterovirus 71 replication and viral 3C protease by quercetin"Virology Journal 15(1):116. doi: 10.1186/s12985-018-1023-6.
38.Min Chen, Ni Li, Nan Wang, Hu Kanghong et al. 2018 "Synthesis, structure and antitumor studies of a novel decavanadate complex with a wavelike two-dimensional network"Polyhedron 155:313-319.
39.Yao Chengguang#, Hu Kanghong# et al. 2019 "Transcriptomic analysis of cells in response to EV71 infection and 2Apro as a trigger for apoptosis via TXNIP gene" Genes & Genomics 41(3):343-357. doi: 10.1007/s13258-018-0760-7
40.Xiaokang Hu, Huan Wang, Bo Huang, Ni Li, Kanghong Hu* et al. 2019 "A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities"Journal of Inorganic Biochemistry 193:130-132
41.Wei Yanhong, Wang Haijie, Xi Caili, Li Ni, Li Dong, Yao Chengguang, Sun Ge, Ge Hongmei, Hu Kanghong* and Zhang Qian* 2020 “Antiviral effects of novel 2-benzoxyl-phenylpyridine derivatives” Molecules 25,1409;doi:10.3390/molecules25061409
国内外授权专利
1.胡康洪等“一种抗HBV诱饵适体及其筛选方法”发明专利授权号：ZL 201110410737.7
2.胡康洪等“利用慢病毒载体介导RNAi的方法”发明专利授权号：ZL 201110110644.2
3.胡康洪等“人原代肝细胞与肝非实质细胞共培养方法”发明专利授权号：ZL 201310282851.5
4.胡康洪“三维灌流式细胞培养器及其应用”发明专利授权号：ZL 201410024728.8
5.胡康洪等“N-甲酰基-3,4-亚甲二氧基苄基-γ-丁内酯在制备抗乙型肝炎病毒药物中的应用”发明专利授权号：ZL 201610407438.0
6.胡康洪等“一种批量简易移液枪头装盒装置”发明专利授权号：ZL 201510596259.1
7.魏艳红，胡康洪等“吡啶杂环酯类化合物在制备抗柯萨奇病毒B3型的药物中的应用”发明专利授权号：ZL 201611192749.6
8.魏艳红，胡康洪等“芳香酯类化合物在制备抗肠道病毒71型药物中的应用”发明专利授权号：ZL 201611192748.1
9.胡康洪“一种三维灌流式细胞分离器”实用新型专利授权号：ZL 201420033628.7
10.胡康洪等“一种酶标板清洗器”实用新型专利授权号：ZL201620514335.X
11.胡康洪等“一种用于深层挫裂伤的免缝合式医用拉链”实用新型专利授权号：ZL 201420699686.3
12.胡康洪等“一种复合维生素营养霜及其脂质体包覆物的制备方法”发明专利申请号：ZL 201710201247.3
13.胡康洪等“一种对HBV易感的人胎肝细胞分离、冻存与复苏方法及应用”发明专利申请号：ZL 201410009255.4
14.胡康洪等“亚硒酸钠在制备治疗或预防乙型肝炎病毒感染药物中的应用”发明专利申请号：ZL 201410009255.4
