主要成就
代表性论文:1) Li ZL#, Lv LL#*, Tang TT, Wang B, Feng Y, Zhou LT, Cao JY, Tang RN, Wu M, Liu H, Crowley SD, Liu BC*. HIF-1a inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation. Kidney Int. 2019 Feb;95(2):388-404. (IF=8.306) (共同一作/共同通讯)2) Tang TT, Lv LL*, Wang B, Cao JY, Feng Y, Li ZL, Wu M, Wang FM, Wen Y, Zhou LT, Ni HF, Chen PS, Gu N, Crowley SD, Liu BC*. Employing macrophage-derived microvesicle for kidney-targeted delivery of dexamethasone: An efficient therapeutic strategy against renal inflammation and fibrosis therapeutic strategy against renal inflammation and fibrosis. Theranostics. 2019 Jul 9;9(16):4740-4755. (IF=8.063) (共同通讯作者)3) Lv LL*#, Feng Y, Wu M, Wang B, Li ZL, Zhong X, Wu WJ, Chen J, Ni HF, Tang TT, Tang RN, Lan HY, Liu BC*. Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury. Cell Death Differ. 2020 Jan 27 (1): 210-226 (IF=8.086 )(共同通讯作者)4) Lv LL, Tang P, Li CJ, You YK, Li JH, Huang XR, Ni J, Feng M, Liu BC#, Lan HY#. The pattern recognition receptor, Mincle, is essential for maintaining the M1 macrophage phenotype in acute renal inflammation. Kidney Int. 2017 Mar;91(3):587-602.(IF=8.306)5) Lv LL, Feng Y, Wen Y, Wu WJ, Ni HF, Li ZL, Zhou LT, Wang B, Zhang JD, Crowley SD, Liu BC#. Exosomal CCL2 from tubular epithelial cells is critical for albumin induced tubulointerstitial inflammation. J Am Soc Nephrol. 2018 Mar;29(3):919-935.(IF= 8.547)6) Li ZL, Lv LL*, Wang B, Tang TT, Feng Y, Cao JY, Jiang LQ, Sun YB, Liu H, Zhang XL, Ma KL, Tang RN, Liu BC*. The profibrotic effects of MK-8617 on tubulointerstitial fibrosis mediated by the KLF5 regulating pathway. FASEB J. 2019 Nov;33(11):12630-12643. (IF 5.498) (共同通讯作者)7) Lv LL*#, Feng Y, Tang TT, Liu BC*. New insight into the role of extracellular vesicles in kidney disease. J Cell Mol Med. 2019 Feb;23(2):731-739. (IF=4.302 )(共同通讯作者)8) Feng Y#, Lv LL*#, Wu WJ, Li ZL, Chen J, Ni HF, Zhou LT, Tang TT, Wang FM, Wang B, Chen PS, Crowley SD, Liu BC*. Urinary exosomes and exosomal CCL-2 mRNA as biomarkers of active histological injury in IgA Nephropathy. Am J Pathol. 2018 Nov;188(11):2542-2552. (IF=3.762)(共同一作/共同通讯)9) Lv LL, Wu WJ, Feng Y, Li ZL, Tang TT, Liu BC#. Therapeutic application of extracellular vesicles in kidney disease: promises and challenges. J Cell Mol Med. 2018 Feb;22(2):728-737. (IF =4.302)10) Tang TT, Lv LL#, Pan MM, Wen Y, Wang B, Li ZL, Wu M, Wang FM, Crowley SD, Liu BC#. Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation. Cell Death Dis. 2018 Mar 2;9(3):351. (IF=5.965) (共同通讯) 在研课题:1. 国家自然科学基金面上项目: KIM-1介导小管上皮细胞外泌体吞噬在肾小管间质炎症中的作用及机制研究, 2020年1月至 2023年12月,58万元2. 国家自然科学基金面上项目:巨噬细胞Mincle受体活化在蛋白尿致肾小管间质炎症中的作用及机制研究,2017年1月-2020年12月, 61万元