基金：1. 国家自然科学基金青年基金项目，2020.1-2022.12，负责人2. 江苏省自然科学基金青年基金项目，2019.7-2022.6，负责人3. 南京市留学人员科技创新项目择优资助，2020.1-2022.12，负责人4.（省优势）新进教师人才引进启动费，2019，负责人5. 东南大学基础科研扶持项目，2019.4-2019.12，负责人6. 东南大学中央高校建设一流大学（学科）和特色发展引导专项资金经费，2019    已发表SCI文章：Zhang W*, Chen JL, Qu ML, Backman J, Zhang AN, Liu HY, Zhang XP, Zhou QJ*, Danielson P*. Sustained release of TPCA-1 from silk fibroin hydrogels preserves keratocyte phenotype and promotes corneal regeneration by inhibiting interleukin-1β signaling. Adv Healthc Mater. 2020, 9(17), 2000591. (IF=7.367)Zhang W*, Ling C, Zhang AN, Liu HY, Jiang YJ, Li XL, Sheng RW, Yao QQ*, Chen JL*. An all-silk-derived functional nanosphere matrix for sequential biomolecule delivery and in situ osteochondral regeneration. Bioactive Materials. 2020, 5:832-843. (IF=8.724)Zhang W*, Ling C, Liu HY, Zhang AN, Mao L, Wang J, Chao J, Backman L, Yao QQ*, Chen JL*. Tannic Acid-Mediated Dual Peptide-Functionalized Scaffolds to Direct Stem Cell Behavior and Osteochondral Regeneration. Chem Eng J. 2020, 396:125232. (IF=10.652)Zhang W, Robertson W, Zhao JM, Chen WW, Xu JK. Emerging trend in the pharmacotherapy of osteoarthritis. Front Endocrinol. 2019, 10:431. (IF=3.644)Zhang W, Li Y, Jiang DM, Xie SJ, Zeng MF, Chen JL, Chen LK, Ouyang HW, Zou XH. Promotion of Hernia Repair with High-Strength, Flexible, and Bioresorbable Silk Fibroin Mesh in a Large Abdominal Hernia Model. ACS Biomater Sci Eng 2018, 4, 2067−2080. (IF=4.152)Chen JL#, Zhang W#, Backman J, Kelk P, Danielson P. Mechanical stresspotentiates the differentiation of periodontal ligament stem cells intokeratocytes. Brit J Ophthalmol 2018, 102:562–569. (共同一作；IF=3.611)Zhang W, Chen LK, Chen JL, Wang LS, Gui XX, Ran JS, Xu GW,Zhao HS, Zeng MF, Ji JF, Qian L, Zhou JD, Ouyang HW, Zou XH. Silk Fibroin Biomaterial Shows Safe and Effective Wound Healing in Animal Models and a Randomized Controlled Clinical Trial. Adv Healthc Mater 2017, 6(10), 1700121. (IF=7.367, 正封面文章, highlighted by Advanced Science News, and ChemistryViews.org)Zhang W,Chen JL, Backman J, Malm A, Danielson P. Surface Topography andMechanical Strain Promote Keratocyte Phenotype and Extracellular Matrix Formation in a Biomimetic 3D Corneal Model. Adv Healthc Mater 2017, 6(5), 1601238. (IF=7.367, 正封面文章；highlighted by Advanced Science News)Chen JL#, Zhang W#, Kelk P, Backman J, Danielson P. Substance P and patterned silk biomaterial stimulate periodontal ligament stem cells to form corneal stroma in a bioengineered 3D model. Stem Cell Res Ther. 2017,8:260. (共同一作；IF=5.116)Zhang W, Ouyang HW, Dass CR, Xu JK. Current research on pharmacologic and regenerative therapies for osteoarthritis. Bone Research 2016, 4: 15040. (IF=11.508, ESI前1%高被引论文)Zhang W, Heng BC, Jiang YZ, Ouyang HW. Clinical Translation of Autologous Cell-Based Tissue Engineering Techniques as Class Three Therapeutics in China- Taking Cartilage Tissue Engineering as an Example. Journal of Orthopaedic Translation 2014,2(2): 56-65. (IF=3.986)Zhang W, Chen JL, Tao JD, Jiang YZ, Hu CC, Huang L,Ji JF, Ouyang HW. The use of type 1 collagen scaffold containing stromal cell-derived factor-1 to create a matrix environment conducive topartial-thickness cartilage defects repair. Biomaterials 2013, 34(3):713-723. (IF=10.317)Zhang W, Chen JL, Tao JD, Hu CC, Chen LK, Zhao HS, Xu GW, Heng BC, Ouyang HW. The promotion of osteochondral repair by combined intra-articular injection of parathyroid hormone-related protein and implantation of abi-layer collagen-silk scaffold. Biomaterials 2013, 34(25):6046-6057. (IF=10.317)Zhang W, Chen JL, Zhang SF, Ouyang HW. Inhibitory function of parathyroid hormone-related protein on chondrocyte hypertrophy: the implication for articular cartilage repair. Arthritis Res Ther 2012,14(4):221. (IF=4.103)Chen JL, Zhang W, Liu ZY, Heng BC,Ouyang HW, Dai XS. Physical regulation of stem cells differentiation intoteno-lineage: current strategies and future direction. Cell Tissue Res 2014, 360(2):195-207. (IF=4.044）Chen JL, Zhang W, Liu ZY, Zhu T, Ouyang HW. Characterization and comparison of post-natal rat Achilles tendon-derivedstem cells at different development stages. SciRep 2016, 6: 22946. (IF=3.998)Chen JL, Zhang EC, Zhang W, Liu ZY, LuP, Zhu T, Yin Z, Backman LJ, Liu HH, Chen X, Ouyang HW. Fos promotes earlystage teno-lineage differentiation of TSPCs in tendon. Stem Cells Transl Med 2017,6(11):2009–2019. (IF=6.429)Jiang Y, Cai Y, Zhang W, Yin Z, Tuan RS, Ouyang HW. Human Cartilage-Derived Progenitor Cells from Committed Chondrocytes for Efficient Cartilage Repair and Regeneration. Stem Cells Transl Med 2016,5(6):733-44 (IF=6.429)Zhang SF, Jiang YZ, Zhang W, Chen LK,Tong T, Liu WL, Mu Q, Liu H, Ji JF, Ouyang HW, Zou XH. Neonatal Desensitization Supports Long-Term Survival and Functional Integration of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells in Rat Joint Cartilage Without Immunosuppression. Stem Cells Dev 2013,22(1): 90-101. (IF=3.082)Jiang YZ, Chen LK, Zhang SF, Tong T, Zhang W, Liu WL, Xu GW, Tuan RS, Heng BC, Crawford R, Xiao Y, Ouyang HW. Incorporation of bioactive polyvinylpyrrolidone  iodine within bilayered collagen 1 scaffolds enhances the differentiation and subchondral osteogenesis of MSCs. Acta Biomater 2013,9(9):8089-98. (IF=7.242)Chen JL, Lan J, Liu DL, Backman L, Zhang W, Zhou QJ, Danielson P. Ascorbic Acid Promotes the Stemness of Corneal Epithelial Stem/progenitor Cells and Accelerates Epithelial Wound Healing in the Cornea. Stem Cells Transl Med 2017,6(5):1356-1365. (IF=6.429)Shen WL, Chen JL, Zhu T, Chen LK, Zhang W, Fang Z, Heng BC, Yin Z, Chen X, Ji J, Chen W, Ouyang HW. Intra-Articular Injection of Human Meniscus Stem/Progenitor Cells Promotes Meniscus Regeneration and Ameliorates Osteoarthritis through Stromal Cell-Derived Factor-1/CXCR4-Mediated Homing. Stem Cells Transl Med 2014, 3(3):387-94. (IF=6.429)Cai DD, Zhou FF, Zhang XZ, Mu Q, Li J, Zhang W, Zhu SA, Jiang YZ, Shen WL, Zhang SF, Ouyang HW. Silk-CS scaffold with immuno-inhibition property for joint cartilage repair. Acta Biomater 2017, 63:64-75. (IF=7.242)Zhang SF, Chen LK, Jiang YZ, Cai YZ, Xu GW, Tong T, Zhang W, Wang LL, Ji JF, Shi PH, Ouyang HW. Bi-layer collagen/microporous electrospun nanofiber scaffold improves the osteochondral regeneration. Acta Biomater 2013,9(7):7236-47. (IF=7.242)Shen W, Chen X, Hu Y, Yin Z, Zhu T, Hu J, Chen J, Zheng Z, Zhang W, Ran J, Heng BC, Ji J, Chen W, Ouyang HW. Long-term effects of knitted silk-collagen sponge scaffold on anterior cruciate ligament reconstruction and osteoarthritis prevention. Biomaterials. 2014, 35(28):8154-63. (IF=10.317)发明专利：张薇，陈隆坤，谢淑君。一种胶原基质软骨修复膜、制备方法及应用。专利号：ZL 2014 1 0499517.X张薇，陈隆坤，徐国伟，宣铁锋。含生物活性因子的组织工程软骨支架及其制备方法与应用。专利号：ZL 2015 1 0808397.1书籍章节：生物材料与组织再生。出版中，人民卫生出版社创伤、烧伤与再生医学。2014，人民卫生出版社再生医学 ：基础与临床。2013，人民卫生出版社