主要成就
参与或主持完成国家级科研项目4项,省部级科研项目7项,目前在研国家级科研项目3项,省部级科研项目4项,国际合作项目2项。业已发表学术论文200余篇,其中SCI引用论文35篇。先后多次被IDF、EASD、IDF-WPR、APCDE等国际著名学术会议邀请做学术报告。主编专著2部、副主编3部、参编5部。主持科研项目1.糖尿病的危险因素早期识别、早期诊断技术与切点研究国家重点研发计划(2016YFC1305700)375万 2016.01.01-2021.06.302.胰岛星状细胞和胰岛内皮细胞相互作用对胰岛功能的影响及其机制研究国家自然基金(81870534)57万 2019.01.01-2022.12.03 3.“糖尿病足病全程管理”诊疗规范的建立和推广江苏省科技厅临床医学专项(BK2014010) 200万 2014.8.1-2017.7.314.2型糖尿病大鼠胰岛星状细胞的生物学特性及其活化机制 主持国家自然基金(81370874)75万 2014.1.1-2017.12.315.胰石蛋白/再生蛋白对胰岛纤维化的影响及其细胞分子机制主持国家自然基金(81170716)58万 2012.1.1-2015.12.316.胰腺星状细胞在2型糖尿病胰岛纤维化和β细胞功能减退中的作用主持国家自然基金(30971399)31万 2010.1.1-2012.12.317.糖尿病及其主要慢性并发症中医药防治综合方案的研究 第三分中心第一国家科技支撑计划(2006BAI04A0)24万 2008.1.1-2011.12.318.基于糖尿病自我管理学校和现代信息技术的医院-社区一体化糖尿病教育管理网络的构建及其评价主持江苏省科技厅重点项目(BK2010087) 30万2010.11.30-2013.7.309.糖尿病自我管理指导网络的建立、运用及费用效益评价主持优秀结题江苏省卫生厅重大项目(K200608)10万 2007.1.1-2009.12.3110.胰腺星状细胞在2型糖尿病胰岛纤维化中的作用及其分子机制主持教育部博士点基金(200802860020)6万 2009.1.1-2010.12.3111.Fractalkine和MMP2交互作用介导糖基化终产物致病效应的体外实验研究主持教育部留学人员回国基金 2万2009.1.1-2010.12.3112.同伴支持计划在中国糖尿病教育中的应用主持美国家庭医师协会 3.3万2011.5.1-2012.4.3013.空腹血糖联合餐后尿糖定量检测在社区糖尿病筛查中的价值主持 国际合作项目(30900696)13万 2010.10.1-2011.10.近三年代表性论文:近三年文章1、ChenY, Li W, Qiu S, Vladmir C, Xu X, Sun Zet al. Tea consumption and risk of diabetes in the Chinese population: amulti-centre, cross-sectional study. Br J Nutr. 2020;123(4):428-436.2、XuW, Jones PM, Geng H, Li R, Liu X, Li Y, Lv Q, Liu Y, Wang J, Wang X, Sun Z, Liang J. Islet Stellate CellsRegulate Insulin Secretion via Wnt5a in Min6 Cells. Int J Endocrinol.2020;2020:4708132.3、QiuS, Cai X, Wu T, Sun Z, Guo H,Kirsten J, Wendt J, Steinacker JM, Schumann U. Objectively-MeasuredLight-Intensity Physical Activity and Risk of Cancer Mortality: A Meta-analysisof Prospective Cohort Studies. Cancer Epidemiol Biomarkers Prev.2020;29(5):1067-1073.4、WangX, Xie C, Marathe CS, Malbert CH, Horowitz M, Jones KL, Rayner CK, Sun Z, Wu T. Disparities in gastricemptying and postprandial glycaemia between Han Chinese and Caucasians withtype 2 diabetes. Diabetes Res Clin Pract. 2020;159:107951. 5、ZhouY, Zhou J, Zhang Y, Tang J, Sun B, Sun Zet al. Changes in Intestinal Microbiota Are Associated with Islet Functionin a Mouse Model of Dietary Vitamin A Deficiency. J Diabetes Res. 2020;2020:2354108.6、ZhouY, Zhou J, Sun B, Xu W, Zhong M, Sun Zet al. Vitamin A deficiency causes islet dysfunction by inducing isletstellate cell activation via cellular retinol binding protein 1. Int J BiolSci. 2020;16(6):947-956. 7、Zhou Y, Sun B, Li W, Zhou J, Gao F, Sun Z et al. Pancreatic Stellate Cells:A Rising Translational Physiology Star as a Potential Stem Cell Type for BetaCell Neogenesis. Front Physiol. 2019;10:218. 8、Shi R, Hu J, Li W, Wang Z, Pan Y, Bai M, Mao W, WangX, Zhong M, Yuan Y, Lau J, Sun Z,Zhao S. Protective effects of Clec11a in islets against lipotoxicity viamodulation of proliferation and lipid metabolism in mice. Exp Cell Res.2019;384(1):111613. 9、Qiu S, Cai X, Liu J, Yang B, Zügel M, Steinacker JM, Sun Z, Schumann U. Association betweencirculating cell adhesion molecules and risk of type 2 diabetes: A meta-analysis.Atherosclerosis. 2019 ;287:147-154.10、Li W, Zhou Y, Wang X, Cai M, Gao F, Sun Z et al. A modified in vitro toolfor isolation and characterization of rat quiescent islet stellate cells. ExpCell Res. 2019;384(1):111617.11、Zhou Y, Li W, Zhou J, Chen J, Wang X, Sun Z et al. Lipotoxicity reduces βcell survival through islet stellate cell activation regulated by lipidmetabolism-related molecules. Exp Cell Res. 2019;380(1):1-8.12、Yang Y, Xie B, Ju C, Jin H, Ye X, Yao L, Jia M, Sun Z, Yuan Y. THE ASSOCIATION OFDECREASED SERUM GDNF LEVEL WITH HYPERGLYCEMIA AND DEPRESSION IN TYPE 2 DIABETESMELLITUS. Endocr Pract. 2019;25(9):951-965. 13、Shi R, Wang Y, An X, Ma J, Wu T, Sun Z et al. Efficacy of Co-administration of Liuwei Dihuang Pillsand Ginkgo Biloba Tablets on Albuminuria in Type 2 Diabetes: A 24-Month,Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial. FrontEndocrinol (Lausanne). 2019;10:100.14、Chen J, Guo H, Yuan S, Qu C, Sun Z et al Efficacy of urinary glucosefor diabetes screening: a reconsideration. Acta Diabetol. 2019 ;56(1):45-53.15、Qiu S, Cai X, Yang B, Du Z, Cai M, Sun Z, Zügel M, Michael Steinacker J,Schumann U. Association Between Cardiorespiratory Fitness and Risk of Type 2Diabetes: A Meta-Analysis. Obesity (Silver Spring). 2019;27(2):315-324. 16、Qiu S, Cai X, Liu J, Yang B, Sun Z, Zügel M, Steinacker JM, SchumannU. Association Between Cardiorespiratory Fitness and Risk of Heart Failure: AMeta-Analysis. J Card Fail. 2019;25(7):537-544. 17、Chen J, Qiu S, Guo H, Li W, Sun Z. Increased waist-to-hip ratio is associated with decreasedurine glucose excretion in adults with no history of diabetes. Endocrine. 2019;64(2):239‐245. 18、Chen Y, Li W, Qiu S, Vladmir C, Xu X, Sun Z et al. Tea consumption and riskof diabetes in the Chinese population: a multi-centre, cross-sectional study.Br J Nutr. 2020;123(4):428-436. 19、Wang X, Xie C, Marathe CS, Malbert CH, Horowitz M,Jones KL, Rayner CK, Sun Z, Wu T.Disparities in gastric emptying and postprandial glycaemia between Han Chineseand Caucasians with type 2 diabetes. Diabetes Res Clin Pract. 2020 ;159:107951.20、Qiu S, Cai X, Yin H, Sun Z, Zügel M, Steinacker JM, Schumann U. Exercise training andendothelial function in patients with type 2 diabetes: a meta-analysis.Cardiovasc Diabetol. 2018;17(1):64. 21、Li W, Xie B, Qiu S, Huang X, Chen J, Sun Z et al. Non-lab and semi-labalgorithms for screening undiagnosed diabetes: A cross-sectional study.EBioMedicine. 2018 ;35:307-316. 22、Wang X, Li W, Chen J, Zhao S, Qiu S, Sun Z et al. A TranscriptionalSequencing Analysis of Islet Stellate Cell and Pancreatic Stellate Cell. JDiabetes Res. 2018;2018:7361684. 23、Yang B, Sun J, Yuan Y, Sun Z. Effects of atorvastatin on autophagy in skeletal muscles ofdiabetic rats. J Diabetes Investig. 2018;9(4):753‐761. 24、Chen J, Guo H, Yuan S, Qu C, Sun Z et al. Efficacy of urinaryglucose for diabetes screening: a reconsideration. Acta Diabetol. 2019 ;56(1):45-53.25、Chen J, Qiu SH, Guo HJ, Li W, Sun ZL. Associations of Insulin Levels and Insulin Resistance WithUrine Glucose Excretion Independent of Blood Glucose in Chinese Adults WithPrediabetes and Newly Diagnosed Diabetes. Front Physiol. 2018;9:1666.26、Chen J, Guo HJ, Qiu SH, Li W, Wang XH, Sun Z et al. Identification of NewlyDiagnosed Diabetes and Prediabetes Using Fasting Plasma Glucose and UrinaryGlucose in a Chinese Population: A Multicenter Cross-Sectional Study. Chin MedJ (Engl). 2018;131(14):1652-1657.27、Chen J, Qiu S, Guo H, Li W, Sun Z. Increased waist-to-hip ratio is associated with decreasedurine glucose excretion in adults with no history of diabetes. Endocrine. 2019;64(2):239‐245. 28、Qiu S, Cai X, SunZ, Li L, Zuegel M, Steinacker JM, Schumann U. Heart Rate Recovery and Riskof Cardiovascular Events and All-Cause Mortality: A Meta-Analysis ofProspective Cohort Studies. J Am Heart Assoc. 2017 ;6(5):e005505.29、Yuan Y, Sun H, SunZ. Advanced glycation end products (AGEs) increase renal lipidaccumulation: a pathogenic factor of diabetic nephropathy (DN). LipidsHealth Dis. 2017;16(1):126. 30、Qiu S, Cai X, Sun Z, Li L, Zügel M, Steinacker JM,Schumann U. Association between physical activity and risk of nonalcoholicfatty liver disease: a meta-analysis. Therap Adv Gastroenterol. 2017Sep;10(9):701-713. doi: 10.1177/1756283X17725977. Epub 2017 Aug 25. PMID:28932271; PMCID: PMC5598813. 31、Qiu S, Cai X, SunZ, Zügel M, Steinacker JM, Schumann U. Aerobic Interval Training andCardiometabolic Health in Patients with Type 2 Diabetes: A Meta-Analysis. FrontPhysiol. 2017;8:957.32、Wang Y, Yuan Y, Zhang Y, Lei C, Zhou Y, He J, Sun Z. Serum 1,5-anhydroglucitol levelas a screening tool for diabetes mellitus in a community-based population athigh risk of diabetes. Acta Diabetol. 2017 ;54(5):425-431.