主要围绕“噪声的听觉系统内/外损伤效应及机制”、“认知/情绪行为异常的神经机制”这两大研究方向展开系统研究，所获部分数据已发表于Environ Health Perspect、ELife等高影响因子杂志，并已获多项国家自然科学基金面上项目及国际合作项目支持。近年承担科研项目情况：主持并完成国家自然科学基金面上项目一项（KCNQ1 通道在胰腺β细胞内分泌功能中的作用，2012-2014）；现主持国家自然科学基金面上项目两项（噪声性听力损失对认知功能的损伤效应及其海马相关机制研究，2017-2020；小胶质细胞在噪声性听力 小鼠认知损伤中的作用及机制研究，2021-2023）；现参与国家自然科学基金国际重大合作研究项目一项（听觉障碍疾病的多模态磁共振成像研究，2016-2020）。曾为主参与国家自然科学基金面上项目三项（都已结题）。近年论文发表情况：六年共19篇论文被Web of Science收录，其中第一作者及通讯作者11篇。[1] Kim MJ, Haroon S, Chen GD, Ding D,Wanagat J, Liu L, Zhang Y, White K, Park HJ, Han C, Boyd K, Caicedo I, Evans K,Linser PJ, Tanokura M, Prolla T, Salvi R, Vermulst M, Someya S: Increasedburden of mitochondrial DNA deletions and point mutations in early-onsetage-related hearing loss in mitochondrial mutator mice. Exp Gerontol 2019,125:110675.[2] LiuLJ, Huang Y, Fang C, Zhang HY, Yang J, Xuan CY, Wang FF, Lu HY, Cao SF, WangYF, Li SW, Sha J, Zha MM, Guo M, Wang J: Chronic noise-exposure exacerbatesinsulin resistance and promotes the manifestations of the type 2 diabetes in ahigh-fat diet mouse model. PloS one 2018, 13:16.[3] Liu LJ, Fang C, Yang J, Zhang HY, Huang Y, XuanCY, Wang YF, Li SW, Sha J, Zha MM, Guo M: The effect of noise exposure oninsulin sensitivity in mice may be mediated by the JNK/IRS1 pathway.Environmental health and preventive medicine 2018, 23:8.[4] Liu L, Xuan C, Shen P, He T, Chang Y, Shi L,Tao S, Yu Z, Brown RE, Wang J: Hippocampal Mechanisms Underlying Impairment inSpatial Learning Long After Establishment of Noise-Induced Hearing Loss in CBAMice. Frontiers in systems neuroscience 2018, 12:35.[5] Liu L, Fang C, Yang J, Zhang H, Huang Y, XuanC, Wang Y, Li S, Sha J, Zha M, Guo M: The effect of noise exposure on insulinsensitivity in mice may be mediated by the JNK/IRS1 pathway. Environmentalhealth and preventive medicine 2018, 23:6.[6] Chen H, Shi L, Liu L, Yin S, Aiken S, Wang J:Noise-induced Cochlear Synaptopathy and Signal Processing Disorders.Neuroscience 2018.[7] Zhang GY, Yang M, Liu B, Huang ZC, Li J, ChenJY, Chen H, Zhang PP, Liu LJ, Wang J, Teng GJ: Changes of the directional brainnetworks related with brain plasticity in patients with long-term unilateralsensorineural hearing loss. Neuroscience 2016, 313:149-61.[8] Song Q, Shen P, Li X, Shi L, Liu L, Wang J, YuZ, Stephen K, Aiken S, Yin S: Coding deficits in hidden hearing loss induced bynoise: the nature and impacts. Scientific reports 2016, 6:25200.[9] Shi LJ, Chang Y, Li XW, Aiken SJ, Liu LJ, WangJ: Coding Deficits in Noise-Induced Hidden Hearing Loss May Stem fromIncomplete Repair of Ribbon Synapses in the Cochlea. Frontiers in neuroscience2016, 10:6.[10] Shi L, Chang Y, Li X, Aiken S, Liu L, Wang J:Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss. Neural plasticity2016, 2016:6143164.[11] Liu LJ, Wang FF, Lu HY, Cao SF, Du ZW, WangYF, Feng X, Gao Y, Zha MM, Guo M, Sun ZL, Wang J: Effects of Noise Exposure onSystemic and Tissue-Level Markers of Glucose Homeostasis and Insulin Resistancein Male Mice. Environ Health Perspect 2016, 124:1390-8.[12] Liu LJ, Shen P, He TT, Chang Y, Shi LJ, Tao S,Li XW, Xun QY, Guo XJ, Yu ZP, Wang J: Noise induced hearing loss impairsspatial learning/memory and hippocampal neurogenesis in mice. Scientificreports 2016, 6:9.[13] Zhang GY, Yang M, Liu B, Huang ZC, Chen H,Zhang PP, Li J, Chen JY, Liu LJ, Wang J, Teng GJ: Changes in the default modenetworks of individuals with long-term unilateral sensorineural hearing loss.Neuroscience 2015, 285:333-42.[14]Shi L, Guo X, Shen P, Liu L, Tao S, Li X, SongQ, Yu Z, Yin S, Wang J: Noise-induced damage to ribbon synapses withoutpermanent threshold shifts in neonatal mice. Neuroscience 2015, 304:368-77.[15] Jie H, Tao S, Liu L, Xia L, Charko A, Yu Z,Bance M, Yin S, Robertson GS, Wang J: Cochlear protection against cisplatin byviral transfection of X-linked inhibitor of apoptosis protein across roundwindow membrane. Gene therapy 2015, 22:546-52.[16] Chen YC, Li X, Liu L, Wang J, Lu CQ, Yang M,Jiao Y, Zang FC, Radziwon K, Chen GD, Sun W, Krishnan Muthaiah VP, Salvi R,Teng GJ: Tinnitus and hyperacusis involve hyperactivity and enhancedconnectivity in auditory-limbic-arousal-cerebellar network. eLife 2015,4:e06576.[17] Liu LJ, Wang FF, Lu HY, Ren XM, Zou JH:Chromanol 293B, an inhibitor of KCNQ1 channels, enhances glucose-stimulatedinsulin secretion and increases glucagon-like peptide-1 level in mice. Islets2014, 6:8.[18] Shi L, Liu L, He T, Guo X, Yu Z, Yin S, WangJ: Ribbon synapse plasticity in the cochleae of Guinea pigs after noise-inducedsilent damage. PloS one 2013, 8:e81566.[19] Liu LJ, Wang H, Shi LJ, Almuklass A, He TT,Aiken S, Bance M, Yin SK, Wang J: Silent Damage of Noise on Cochlear AfferentInnervation in Guinea Pigs and the Impact on Temporal Processing. PloS one2012, 7:11.