主要成就
姚红红教授长期潜心研究严重危害人类健康的重大神经系统疾病如脑卒中和抑郁症，围绕这两种疾病的共性病理机制-神经炎性反应，针对目前缺乏有效中枢性抗炎药物和治疗靶点等关键科学问题，聚焦表观遗传学-非编码RNA 等分子生物学前沿，从新的视角阐明重大神经系统疾病的病理机制，为诊疗疾病提供新思路和新型潜在药物。在有重要影响力的SCI 学术刊物Nat Commun，Blood，Mol Psychiatry，Autophagy，J Neurosci 等杂志发表论文98 篇（总IF=447），其中一作或通讯作者论文47篇，H 指数22，总被引1957次，被Nat Rev，Mol Cell，Trends Neurosci 等引用，获得自噬领域专家MIT Shashi Bala和NIH Alexander Pletnev 等教授的高度评价。应药学领域顶级期刊Pharmacol Ther邀撰写综述，相关工作被被Global Medical Discovery 高度评价。参编美国医学生神经科学教材的英文著作3 部。代表性论著：1.Zhou, Zhenhua; Lu, Jianfei; Liu, Wen-Wu; Manaenko, Anatol; Hou, Xianhua; Mei, Qiyong; Huang, Jun-Long; Tang, Jiping; Zhang, John H; Yao, Honghong; Hu, Qin. Advances in stroke pharmacology.Pharmacology & therapeutics.(Epub)2.Yuan Zhang, Longfei Du, Ying Bai, Bing Han, Cancan He, Liang Gong,Rongrong Huang, Ling Shen, Jie Chao, Pei Liu, Hongxing Zhang, Haisan, Zhang, Ling Gu, Junxu Li, Gang Hu, Chunming Xie, Zhijun Zhang,Honghong Yao. CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination. Molecular Psychiatry. (in press)3.Yang L, Han B, Zhang Y, Bai Y, Chao J, Hu G, Yao HH. Engagement of circular RNA HECW2 in the nonautophagic role of ATG5 implicated in the endothelial-mesenchymal transition. Autophagy. 2018;14(3):404-18. doi: 10.1080/15548627.2017.1414755.4.Han B, Zhang Y, Zhang YH, Bai Y, Chen XF, Huang RR, Wu FF, Leng S, Chao J, Zhang JH, Hu G, Yao HH. Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke. Autophagy. 2018;14(7):1164-84. doi: 10.1080/15548627.2018.1458173.5.Bai Y, Zhang Y, Han B, Yang L, Chen XF, Huang RR, Wu FF, Chao J, Liu P, Hu G, Zhang JH, Yao HH. Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity. Journal Of Neuroscience. 2018;38(1):32-50. doi: 10.1523/Jneurosci.1348-17.2017.6.Han B, Chao J, Yao HH. Circular RNA and its mechanisms in disease: From the bench to the clinic. Pharmacology & therapeutics. 2018;187:31-44. doi: 10.1016/j.pharmthera.2018.01.010.7.Huang RR, Zhang Y, Han B, Bai Y, Zhou RB, Gan GM, Chao J, Hu G, Yao HH. Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG. Autophagy. 2017;13(10):1722-41. doi: 10.1080/15548627.2017.1356975.8.Zhang Y, Shen K, Bai Y, Lv X, Huang RR, Zhang W, Chao J, Nguyen LK, Hua J, Gan GM, Hu G, Yao HH. Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity. Autophagy. 2016;12(9):1538-59. doi: 10.1080/15548627.2016.1191723.9.Liu HJ, Fang SC, Wang W, Cheng YS, Zhang YM, Liao H, Yao HH, Chao J. Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy. Particle and fibre toxicology. 2016;13. doi: ARTN 5510.1186/s12989-016-0167-z.10.Yao H, Ma R, Yang L, Hu G, Chen XF, Duan M, Kook Y, Niu F, Liao K, Fu MG, Hu G, Kolattukudy P, Buch S. MiR-9 promotes microglial activation by targeting MCPIP1. Nature communications. 2014;5. doi: Artn 438610.1038/Ncomms5386.11.Yao HH, Yang YJ, Kim KJ, Bethel-Brown C, Gong N, Funa K, Gendelman HE, Su TP, Wang JQ, Buch S. Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. Blood. 2010;115(23):4951-62. doi: 10.1182/blood-2010-01-266221.12.Yao HH, Duan M, Buch S. Cocaine-mediated induction of platelet-derived growth factor: implication for increased vascular permeability. Blood. 2011;117(8):2538-47. doi: 10.1182/blood-2010-10-313593.
