承担课题1.    糖尿病肾病早期监测与适宜替代治疗新技术研究与推广，国家重点研发计划(2018YFC1314000)，1222万，2018.9-2020.122.    Exosomal miRNA介导肾小管上皮细胞-巨噬细胞对话的新机制研究,国家自然科学基金重大国际合作项目（81720108007），248万元, 2018.01—2022.123.    基于尿液肾脏固有细胞mRNAs分析的肾脏纤维化生物标志物发现与鉴定，国家自然科学基金面上项目（81670696），58万元，2017.01-2020.114.    PTH诱导血管内皮-软骨细胞转分化在CKD血管钙化发生中的作用和机制研究，国家自然科学基金面上项目（81470997），130万元，2015.01-2018.115.    江苏省医学重点学科（江苏省科技强卫工程），250万元，2016.01-2020.11代表性论著1.    Zhang Y, Ma KL, Gong YX, Wang GH, Hu ZB, Liu L, Lu J, ChenPP, Lu CC, Ruan XZ, Liu BC. Platelet Microparticles Mediate Glomerular Endothelial Injury in Early Diabetic Nephropathy. J Am Soc Nephrol. 2018 Nov;29(11):2671-2695. （IF= 8.966）2.    Liu BC, Tang TT, Lv LL, Lan HY. Renal tubuleinjury: a driving force toward chronic kidney disease. Kidney Int. 2018Mar;93(3):568-579. （IF=8.395）3.    Tang TT, Lv LL, Pan MM, Wen Y, Wang B, Li ZL, Wu M, WangFM, Crowley SD, Liu BC. Hydroxychloroquineattenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediatedNLRP3 inflammasome activation. Cell Death Dis. 2018 Mar2;9(3):351.  (IF=5.965)4.    Zuo-Lin Li#, Lin-Li Lv#, Tao-Tao Tang, Bin Wang, Ye Feng,Le-Ting Zhou, Jing-Yuan Cao, Ri-Ning Tang1, Min Wu1, Hong Liu, Steven DCrowley, Bi-Cheng Liu. HIF-1a inducing exosomal microRNA-23a expressionmediates the cross-talk between tubular epithelial cells and macrophages intubulointerstitial inflammation. Kidney Int  2019 Feb;95(2):388-404.（IF=8.395）5.    Lv LL, Feng Y, Wen Y, Wu WJ,  Ni HF, Li ZL, Zhou LT, Wang B, Zhang JD, Crowley SD, Liu BC. Exosomal CCL2 from tubular epithelial cells is critical for albumin inducedtubulointerstitial inflammation. J Am Soc Nephrol. 2018 Mar;29(3):919-935.（IF= 8.966）6.    Wang B, Wang ZM, Ji JL, Gan W, Zhang A, Shi HJ, Wang H, Lv L, Li Z, Tang T, Du J, Wang XH, Liu BC. Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy. JACC Basic Transl Sci. 2020 Jan 15;5(2):148-166. 7.    Wang B, Zhang A, Wang H, Klein JD, Tan L, Wang ZM, Du J, Naqvi N, Liu BC, Wang XH. miR-26a Limits Muscle Wasting and Cardiac Fibrosis through Exosome-Mediated microRNA Transfer in Chronic Kidney Disease. Theranostics. 2019 Mar 7;9(7):1864-1877.8.    Wen Y, Lu X, Ren J, Privratsky JR, Yang B, Rudemiller NP, Zhang J, Griffiths R, Jain MK, Nedospasov SA, Liu BC, Crowley SD. KLF4 in Macrophages Attenuates TNFα-Mediated Kidney Injury and Fibrosis. J Am Soc Nephrol. 2019 Oct;30(10):1925-1938. 9.    Lv LL, Tang P, Li CJ, You YK, Li JH, Huang XR, Ni J, FengM, Liu BC, Lan HY. The pattern recognition receptor, Mincle, is essential formaintaining the M1 macrophage phenotype in acute renal inflammation. Kidney Int. 2017 Mar;91(3):587-602.（IF=8.395）10.  Chen N, Hao C, Peng X, Lin H, Yin A, Hao L, Tao Y, Liang X, Liu Z, Xing C, Chen J, Luo L, Zuo L, Liao Y, Liu BC, Leong R, Wang C, Liu C, Neff T, Szczech L, Yu KP. Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis.  N Engl J Med. 2019 Sep 12 381 (11), 1001-101011.  Chen N, Hao C, Liu BC, Lin H, Wang C, Xing C, Liang X, Jiang G, Liu Z, Li X, Zuo L, Luo L, Wang J, Zhao MH, Liu Z, Cai GY, Hao L, Leong R, Wang C, Liu C, Neff T, Szczech L, Yu KP. Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis. N Engl J Med. 2019 Sep 12 381 (11), 1011-102212.  Zhang L, Wang F, Wang L, Wang W, Liu BC, Liu J, Chen M, He Q, Liao Y, Yu X, Chen N, Zhang JE, Hu Z, Liu F, Hong D, Ma L, Liu H, Zhou X, Chen J, Pan L, Chen W, Wang W, Li X, Wang H. Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet. 2012 Mar 3;379(9818):815-22.13.  Renal Fibrosis: Mechanisms and Therapies.  Liu BC, Lan HY, Lv LL edt. Springer, 2020