最后学位：理学博士（Ph.D.，中国科学院） 职称职务：教授、博导 专业方向：免疫学 研究方向：病毒免疫、肿瘤免疫 电话号码：68750006 电子邮件：chengliang0204@aliyun.com |
教育经历
2002-2006 武汉大学生命科学学院 学士
2007-2011 中国科学院生物物理研究所 博士
工作经历与任职
2011-2014 美国北卡罗莱纳大学教堂山分校 博士后
2014-2018 美国北卡罗莱纳大学教堂山分校 研究助理
2018-2020 美国北卡罗莱纳大学教堂山分校 研究助理教授
2020-至今 武汉大学医学研究院 教授
获奖情况
2018 New Investigator Scholarship, Conference on Retroviruses and Opportunistic Infections (CROI)
2017 美国免疫学家学会“Abstract Award”
2016 美国免疫学家学会“Abstract Award”
2015 美国免疫学家学会“Abstract Award”
2011 中国科学院地奥奖学金, 中国
学术兼职
2019 – 至今 Associate Editor, BMC immunology
研究领域
实验室主要研究慢性病毒感染的免疫致病机制及免疫治疗。我们利用独特的人源化小鼠模型，结合临床标本，运用免疫学、遗传学、转录及代谢组学等手段，研究HIV等病毒慢性感染导致机体持续异常炎症、免疫代谢紊乱、T细胞功能耗竭的调控机制，并致力于开发新的免疫治疗策略。同时，我们研究肿瘤炎症微环境对免疫细胞表型及功能的调控作用，以挖掘肿瘤免疫治疗新靶点。
代表性论文
1. L Cheng, Q Wang, G Li, J Ma, H Yu, F Yasui, Z Zhang, S Zurawski, G Zurawski, Y Levy, L Su. TLR3 agonist/CD40-targeting vaccination induces T cell response and reduces HIV-1 reservoirs. The Journal of Clinical Investigation.128(10):4387-4396. (2018).
2. L Cheng*, J Ma, G Li, L Su*. Humanized mice engrafted with human HSC only or HSC and thymus support comparable HIV-1 replication, immunopathology and responses to ART and immune therapy. Frontiers in Immunology. Apr 19; 9:817. (2018). *Co-corresponding author.
3. J Zhao#,L Cheng#, H Wang, H Yu, B Tu, Q Fu, G Li, Q Wang, Z Liu, L Zhang, L Su, Z Zhang. Infection and depletion of CD4+ group-1 innate lymphoid cells by HIV-1 via type-I interferon pathway. PLoS pathogens.Jan 5; 14(1): e1006819. (2018). #Equal contribution
4. L Cheng#, J Ma#, J Li#, D Li, G Li, F Li, Q Zhang, H Yu, F Yasui, C Ye, L-C Tsao, Z Hu, L Su, L Zhang. Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs.The Journal of Clinical Investigation. 127(1), 269-279. (2017) (Editor’s Pick; Commentary by Steven G. Deeks et al., JCI, 127:103-105. Highlight in Editors' Choice by Science Translational Medicine.)
5. L Cheng*, H Yu, G Li, F Li, J Ma, J Li, L Chi, L Zhang*, L Su*. Type I Interferons Suppress Viral Replication but Contribute to T Cell Depletion and Dysfunction during Chronic HIV-1 Infection. JCI Insight. 2(12): e94366. (2017) . *Co-corresponding author.
6. . L Cheng, Z Zhang, G Li, F Li, L Wang, L Zhang, S Zurawski, G Zurawski, Y Levy, L Su. Human innate responses and adjuvant activity of TLR ligands in vivo in mice reconstituted with a human immune system. Vaccine.Sep 25. pii: S0264-410X (17)31300-2. (2017).
7. Z Zhang#,L Cheng#, J Zhao#, G Li, L Zhang, W Chen, W Nie, N-J Reszka-Blanco, F-S Wang, L Su. Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion. The Journal of Clinical Investigation.125, 3692-3703.(2015). # Equal contribution. (Editor’s Pick; Commentary by Yang-Xin Fu et al., JCI, 125:3430-31.)
8. L Cheng, F Li, M Bility, C Murphy, and L Su. Modeling hepatitis B virus infection, immunopathology and therapy in mice.Antiviral research.121, 1-8. (2015).
9. L Cheng#, X Du#, Z Wang, J Ju, M Jia, Q Huang, Q Xing, M Xu, Y Tan, M Liu, P Du, L Su, S Wang. Hyper-IL-15 suppresses metastatic and autochthonous liver cancers by promoting tumor-specific CD8 T cell responses. Journal of Hepatology. 61, 1297-1303. (2014). # Equal contribution.
