教育经历

1999-2003  武汉大学生命科学学院，学士

2004-2010  武汉大学生命科学学院，博士；导师：付向东教授

工作经历与任职

2011-2017 美国加州大学圣地亚哥分校医学院细胞与分子医学系，博士后；导师：付向东教授

2017至今 武汉大学医学研究院，教授/博导

研究领域

  RNA结合蛋白在基因转录后的剪接加工、修饰、转运、细胞定位、稳定性、翻译和降解等生物学过程中发挥经典的RNA调控功能；同时，我们近期的一系列研究发现RNA结合蛋白还是一类新型转录因子，它们通过RNA依赖的染色质相互作用直接参与转录调控，开辟了RNA结合蛋白功能研究的新领域[Xiao et al. 2019 Cell；Van Nostrand et al. 2020 Nature (in press); Ji et al. 2013 Cell; Wei et al. 2016 Mol Cell]。本实验室主要采用多组学技术（ChIP-seq、GRO-seq、CLIP-seq、RNA-seq、Hi-C和GRID-seq等），系统地研究RNA结合蛋白的RNA调控、转录与染色质调控功能和相关疾病的发生机制。

获奖、荣誉、学术兼职

Advanced Science等杂志应邀审稿人

目前研究资助

国家自然科学基金面上项目、国家重点研发计划重点专项等。

代表性论文

1. Xiao, R.#*, Chen, JY#, Liang, Z#, Luo, D., Chen, G., Lu, Z., Chen, Y., Zhou, B., Li, H., Du, X., Yang, Y., San, M., Wei, X., Liu, W., Lecuyer, E., Graveley, B., Yeo, G., Burge, C., Zhang, M., Zhou, Y. and Fu, XD* (2019) Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-based Regulation of Transcription. Cell. 178(1):107-121.

2. Van Nostrand, E.#, Freese, P.#, Pratt, G.#, Wang, X.#, Wei, X.#, Xiao, R.#, Blue, S., Chen, J., Cody, N., Dominguez, D., Olson, S., Sundararaman, B, Zhan, L., Bazile, C., Bouvrette, L., Bergalet, J., Duff, M., Garcia, K., Gelboin-Burkhart, C., Hochman, M., Lambert, N., Li, H., Nguyen, T., Palden, T., Rabano, I., Sathe, S., Stanton, R., Su, A., Wang, R., Yee, B., Zhou, B., Louie, A., Aigner, S., Fu, XD*, Lécuyer, E.*, Burge, C.*, Graveley, B.*, Yeo, G.*（2020）A Large-Scale Binding and Functional Map of Human RNA Binding Proteins. Nature (in press). 预印版已在bioRxiv发表，http://doi.org/10.1101/179648.

3. Wang, L.#, Zhou, Y.#, Xu, L.#, Xiao, R.#, Lu, X., Chen, L., Chong, J., He, C., Fu, XD and Wang, D. (2015) Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature. 523(7562):621-625.

4. Wei, C.#, Xiao, R.#, Chen, L.#, Cui, H.#, Zhou, Y.#, Xue, Y., Hu, J., Zhou, B., Tsutsui, T., Qiu, J., Li, H., Tang, L. and Fu, XD (2016) RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes. Molecular Cell. 62(6):875-889.

5. Xiao, R.#, Tang, P.#, Yang, B., Huang, J., Zhou, Y., Shao, C., Li, H., Sun, H., Zhang, Y. and Fu, XD (2012) Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation. Molecular Cell. 45(5):656-668.

6. Ji, X., Zhou, Y., Pandit, S., Huang, J., Li, H., Lin, C., Xiao, R., Burge, C.B. and Fu, XD (2013) SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase. Cell. 153(4):855-68.

7. Chen, L., Chen, JY., Zhang, X., Gu, Y., Xiao, R., Shao, C., Tang, P., Qian, H., Luo, D., Li, H., Zhou, Y., Zhang, D., and Fu, XD (2017) R-ChIP using inactive RNase H reveals dynamic Coupling of R-loops with transcriptional pausing at gene promoters. Molecular Cell. 68(4): 745-57.