您好,欢迎来到达州工业云! 平台首页 企业驾驶舱 帮助中心 企业登录 企业注册

HI,欢迎使用达州工业云平台!

账号必须大于2位

创新资源平台
服务平台首页>协同创新>专家库>专家详情

吴 更(研究员)

所属单位:上海交通大学微生物代谢国家重点实验室

担任职务:研究员

擅长领域:

联系方式:021-34205914 邮箱:登录后查看

 个人简介

1997年在中国科学技术大学生物系获学士学位,2001年在普林斯顿大学化学系获博士学位。发表SCI论文44篇,被引用超过2200次。曾分别在NatureMolecular CellScience上发表第一作者论文,已分别被引用464次、281次和152次。所解析的Smac-XIAP蛋白质复合物的晶体结构被GenentechNovartis等制药公司作为研发抗癌药物的参考依据,研发出的某些化合物已用于临床实验。2008年开始在上海交大担任教授、博士生导师,作为独立PI建立了上海交大第一个、也是目前上海交大闵行校区唯一一个结构生物学实验室。以通讯作者身份在Cell ResearchMolecular MicrobiologySCI期刊上发表8篇论文。获上海市“东方学者”特聘教授(2008)、上海市“曙光学者”(2008)、上海市“浦江人才”(2009)、教育部“新世纪优秀人才”(2009)等荣誉。读博士、博士后期间,在Nature(2000年,该论文被Novartis等制药公司作为开发抗癌药物的参考依据)、Science(2000年)、Molecular Cell(2003, 2004年)发表第一作者论文。在交大期间,在Nature Communications (2013, 2017年)、Cell Research(2012年, 该论文被英国皇家学会院士Mariann Bienz选入国际生物医药类论文权威数据库Faculty of 1000)、Nucleic Acids Research(2014年)、Molecular Microbiology(2013, 2014年)、Journal of Molecular Cell Biology(2016年)、Cell Discovery(2015, 2016年)等发表通讯作者或第一作者论文。

教育经历

1999.5 2001.5  普林斯顿大学(美国) 化学系  博士

1997.8 1999.5  普林斯顿大学(美国) 化学系  硕士

1992.9 1997.7  中国科学技术大学   生物系  学士  化学物理学辅修学位

1997 -  2001    普林斯顿大学      化学系  硕士、博士学位

工作经历

2008.6–现在     上海交通大学生命科学技术学院  教授、博士生导师

2003.62008.6   哈佛大学医学院/波士顿儿童医院(美国) 博士后

2001.62003.6   Memorial Sloan Kettering癌症研究所/Howard Hughes Medical Institute(美国) 博士后

荣誉奖励

获美国Leukemia and Lymphoma Society的Special Fellowship(2005-2008年)、上海市“东方学者”特聘教授(2008年)与上海市“东方学者”跟踪计划(2014年)、上海市“曙光计划”(2008年)、教育部 “新世纪优秀人才”(2009年)、上海市“浦江人才”(2009年)等荣誉。荣获教育部“高等学校科学研究优秀成果奖(科学技术)”自然科学一等奖(排名第四,2016年)。指导的博士生张振义荣获2014年上海市优秀博士论文。


 

 

 

主要成就


  • 代表性论文(*:共同通讯作者,#:并列第一作者)

    1.         Kulaberoglu Y#, Lin K#, Holder M, Gai Z, Gomez M, Shifa BA, Mavis M, Hua L, Sharif AAD, Lujan C, Smith EJ, Bjedov I, Tapon N, Wu G*, Hergovich A*. Stable MOB1 interaction with Warts/LATS, not Hippo/MST, is essential for development and tissue growth control in Hippo signaling. Nat Commun Accepted. (2017)
    2.         Qian T, Wo J, Zhang Y, Song Q, Feng G, Luo R, Lin S*, Wu G*, Chen HF*. Crystal structure of StnA for the biosynthesis of antitumor drug streptonigrin reveals a unique substrate binding mode. Sci Rep 7:40254. (2017)
    3.         Gai Z, Wang Q, Yang C, Wang L, Deng W, Wu G*. Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway. Cell Discov 2:16051. (2016)
    4.         Gai Z, Chu W, Deng W, Li W, Li H, He A, Nellist M, Wu G*. Structure of the TBC1D7-TSC1 complex reveals that TBC1D7 stabilizes dimerization of the TSC1 C-terminal coiled coil region. J Mol Cell Biol 8:411-425. (2016)
    5.         Zhao G, Chen C, Xiong W, Gao T, Deng Z, Wu G*, He X*. Structural basis of the substrate preference towards CMP for a thymidylate synthase MilA involved in mildiomycin biosynthesis. Sci Rep 6:39675. (2016)
    6.         Zhang Z, Akyildiz S, Xiao Y, Gai Z, An Y, Behrens J*, Wu G*. Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners. Cell Discov 1:15016. (2015)
    7.         Wu G#, Chen D#, Tang H#, Ren Y, Chen Q, Lv Y, Zhang Z, Zhao YL*, Yao Y, Xu P*. Structural insights into the specific recognition of N-heterocycle biodenitrogenation-derived substrates by microbial amide hydrolases. Mol Microbiol 91:1009-1021. (2014)
    8.         Zhao G#, Wu G#, Zhang Y, Liu G, Han T, Deng Z, He X*. Structure of the N-glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23 specifically recognizes the substrate and controls its entry. Nucleic Acids Res 42:8115-24. (2014)
    9.         Zhang Y, Fu L, Qi X, Zhang Z, Xia Y, Jia J, Jiang J, Zhao Y*, Wu G*. Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nat Commun 4:2608. (2013)
    10.     Chen D, Tang H, Lv Y, Zhang Z, Shen K, Lin K, Zhao YL, Wu G*, Xu P*. Structural and computational studies of the maleate isomerase Iso from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside. Mol Microbiol 87:1237-1244. (2013)
    11.     Zhang Z, Chen L, Gao L, Lin K*, Zhu L, Lu Y, Shi X, Gao Y, Zhou J, Xu P, Zhang J*, Wu G*. Structural basis for the recognition of Asef by Adenomatous Polyposis Coli. Cell Res 22:372-386. (2012) 被英国皇家学会院士Marian Bienz选入Faculty of 1000数据库
    其他SCI论文:
    12.     Jiang H, Deng R, Yuang X, Shang J, Lu S, Zhao Y, Song K, Liu X, Zhang Q, Chen Y, Chinn YE, Wu G, Li J, Chen G, Yu J*, Zhang J*. Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat Chem Biol Accepted. (2017)
    13.     Zhang K, Wu G, Tang H*, Hu C, Shi T, Xu P*. Structural basis for the transcriptional repressor NicR2 in nicotine degradation from Pseudomonas. Mol Microbiol 103:165-180. (2017)
    14.     21. Liu G, Zhang Z, Zhao G, Deng Z, Wu G*, He X*. Crystallization and preliminary X-ray analysis of the type IV restriction endonuclease ScoMcrA from Streptomyces coelicolor, which cleaves both Dcm-methylated DNA and phosphorothioated DNA. Acta Crystallogr F 71:57-60. (2015)
    15.     Jiang Y, Tang H*, Wu G, Xu P*. Functional identification of a novel gene, moaE, for 3-succinoylpyridine degradation in Pseudomonas putida S16. Sci Rep 5:13464. (2015)
    16.     Zhang Y, An J, Yang G, Bai A, Zheng B, Lou Z, Wu G, Ye W, Chen HF, Feng Y*, Manco G*. Active site loop conformation regulates promiscuous activity in a lactonase from Geobacillus kaustophilus HTA426. PLoS One 10:e0115130. (2015)
    17.     Wang H, Zhang Y, Zhang Z, Jin WL*, Wu G*. Purification, crystallization and preliminary X-ray analysis of the inverse F-BAR domain of the human srGAP2 protein. Acta Crystallogr F 70:123-126. (2014)
    18.     Xie Y, An J, Yang G, Wu G, Zhang Y, Cui L, Feng Y*. Enhanced enzyme kinetic stability by increasing rigidity within the active site. J Biol Chem 289:7994-8006. (2014)
    19.     Li A, Zhang Y*, Wang C, Wu G*, Wang Z. Purification, molecular cloning, and antimicrobial activity of peptides from the skin secretion of the black-spotted frog, Rana nigromaculata. World J Microbiol Biotechnol 29:1941-1949 (2013)
    20.     Chen F, Zhang Z, Lin K*, Qian T, Zhang Y, You D, He X, Wang Z, Liang J, Deng Z, Wu G*. Crystal structure of the cysteine desulfurase DndA of Streptomyces lividans which is involved in DNA phosphorothioation. PLoS One 7:e36635. (2012)
    21.     Hu W, Wang C, Liang J, Zhang T, Hu Z, Wang Z, Lan W, Li F, Wu H, Ding J, Wu G, Deng Z, Cao C*. Structural insights into DndE from Escherichia coli B7A involved in DNA phosphorothioation modification. Cell Res 22:1203-1206. (2012)
    22.     Tang H, Yao Y, Wang L, Yu H, Ren Y, Wu G, Xu P*. Genomic analysis of Pseudomonas putida: genes in a genome island are crucial for nicotine degradation. Sci Rep 2:377. (2012)
    23.     Li Q, Feng J, Gao C, Li F, Yu C, Meng L, Zhang Z, Ma C*, Gu L*, Wu G, Xu P. Purification and characterization of a flavin reductase from the biodesulfurizing bacterium Mycobacterium goodii X7B. Process Biochem 47:1144-1149. (2012)