侯琦，女，研究员，博士生导师。现就职于中国医学科学院药物研究所药理室，任抗炎免疫课题组组长。近年来承担或参与国家自然科学基金面上项目等众多项科研项目，在Apoptosis，JBC、JLR等期刊上发表研究论文20多篇，申请专利10多项，并获得科技奖励2项。

联系电话：010-63165191, 010-63165192； 邮箱：houq@imm.ac.cn

教育背景

2001/02 – 2003/05，南卡罗莱那医科大学（MUSC，USA），博士后

 1997/9-2000/6, 中国医学科学院药物研究所，博士

 1989/09 - 1991/06，山东大学医学院，硕士

 1982/09-1987/06   滨州医学院，学士

工作经历

2007/03 - 至今，中国医学科学院药物研究所，研究员。

 2003/5-2007/3，MUSC，USA，助理教授

1987/9-1997/6 潍坊医学院，天然药物与药理学研究室，副教授

专业研究领域

1.       抗炎免疫相关新药的主要药效学评价研究

2.       哮喘、COPD气道炎症调控靶点及其创新药物的发现研究

3.       风湿性、类风湿性以及骨关节炎药物发现及机制研究

4.       再生障碍性贫血免疫病理机制及其调控药物研究

5.       基于免疫复合物-抗原-免疫磁珠筛选中药等复杂成分中致敏原及其致敏机制研究

近5年内发表的主要研究论文

[1]  Yuanyuan Zhuang^#, Jiabao Liu^#, Pei Ma^#, Jinye Bai, Yasi Ding, Hui Yang, Yannan Fan, Mingbao Lin^*, Shuai Li^*, Qi Hou^*. Tamarixinin A alleviates joint destruction of rheumatoid arthritis by blockade of MAPK and NF-κB activation. Frontiers in Pharmacology. 2017, 8: 538.

[2] Lingling Xuan, Rentao Jiang, Zhiyuan Wu, Honggan Yi, Chunsuo Yao, Qi Hou*, Chunfeng Qu*. Vam3, a Compound Derived from Vitis amurensis Rupr., Attenuated Colitis-Related Tumorigenesis by Inhibiting NF-kappa B Signaling Pathway , Frontiers in Pharmacology, 2016.9.13, 7.

[3]  Yunxiao Li, Ganggang Y u, Shaopeng Yuan, Chunting Tan, Jianlin Xie, Yasi Ding, Puqiao Lian, Lixia Fu, Qi Hou*, Bo Xu*, Haoyan Wang*.  14,15- Epoxyeicosatrienoic acid suppresses cigarette smoke condensate-induced inflammation in lung epithelial cells by inhibiting autophagy, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2016.11.1, 311(5): L970~L980.

[4]  Junling Zhang, Xiaolei Xue, Xiaodan Han, Chunsuo Yao, Lu Lu, Deguan Li, Qi Hou*, Weimin Miao, Aimin Meng*, Saijun Fan*. Vam3 ameliorates total body irradiation-induced hematopoietic system injury partly by regulating the expression of Nrf2-targeted genes , FREE RADICAL BIOLOGY AND MEDICINE, 2016.12, 101: 455~464.

[5]  Pei Ma^#, Yasi Ding^#, Lingling Xuan^#, Lin Wang, Ji Shi, Jinye Bai, Mingbao Lin*, Wensheng Zheng^*, Qi Hou*. Anti-inflammatory effect of a resveratrol derivative 3,4,5-trimethoxy-4′, 5′-dihydroxytrans-stilbene (WL-09-5) via ROS-mediated NF-κB pathway. Journal of Asian Natural Products Research. 2016, 18(10): 1004-1013

[6]  Mingbao Lin, Wei Sun, Wan Gong, Zhiyu Zhou, Yasi Ding, Qi Hou*. Methylophiopogonanone A Protects against Cerebral Ischemia/Reperfusion Injury and Attenuates Blood-Brain Barrier Disruption In Vitro [J]. PLoS ONE, 2015; 10(4): e0124558. doi:10.1371/journal.pone.0124558.

[7] Mingbao Lin, Wei Sun, Wan Gong, Yasi Ding, Yuanyan Zhuang, Qi Hou*. Ginsenoside Rg1 protects against transient focal cerebral ischemic injury and suppresses its systemic metabolic changes in cerabral injury rats [J]. Acta Pharmaceutica Sinica B, 2015; 5(3): 277–284.

[8] Weibin Tang#, Jianlin Xie#, Song Xu, Haining Lv, Mingbao Lin, Shaopeng Yuan, Jinye Bai, Qi Hou*, and Shishan Yu*. Novel Nitric Oxide-Releasing Derivatives of Brusatol as Anti-Inflammatory Agents: Design, Synthesis, Biological Evaluation, andNitric Oxide Release Studies [J]. Journal of Medicinal Chemistry, 2014(57): 7600-7612.

[9] Ling-ling XUAN, Ji SHI, Chun-suo YAO, Jin-ye BAI, Feng QU, Jin-lan ZHANG, Qi HOU*. Vam3, a resveratrol dimer, inhibits cigarette smoke-induced cell apoptosis in lungs by improving mitochondrial function [J]. Acta Pharmacologica Sinica, 35(2014): 779-791.

[10] Shaopeng Yuan, Shuhua Cao, Rentao Jiang, Renping Liu, Jinye Bai, Qi Hou*. FLLL31, a derivative of curcumin, attenuates airway inflammation in a multi-allergen challenged mouse model[J]. International Immunopharmacology, 21(2014): 128-136.