李创军，博士，副研究员，硕士研究生导师。

教育背景：

1998.9-2002.7 甘肃中医学院，本科。

2002.9-2005.7 江西中医学院，中药学，获理学硕士学位。

2005.9-2008.7 中国医学科学院北京协和医学院，药物研究所，获理学博士学位。

工作背景：

2008年7月至2009年3月，悦康药业

2009.4至今：中国医学科学院药物研究所

联系方式：

Tel: 010-60212113; E-mail: lichuangjun@imm.ac.cn

专业研究领域：

天然药物中活性成分的发现和结构修饰。近年来主要对多种中草药中的倍半萜、三萜及混源萜类活性成分进行了研究。作为课题负责人主持国家自然科学青年基金1项，药物所基本科研业务费2项。作为课题骨干参与了2项国家科技支撑计划项目、“十一五”重大新药创制等多个课题的研究工作。近年发表第一作者文章12篇，申请专利4项。曾获得2013年度北京市科学技术一等奖（排名第15）、2013年度教育部科学技术进步二等奖（排名第15）和2012年度中国医学科学院药物研究所“梁周黄于刘青年科技奖”二等奖。

近年发表论文

1. Chuang- Jun Li, Jie Ma, Hua Sun, Dan Zhang, Dong-Ming Zhang*. Guajavadimer A, a dimeric caryophyllene-derived meroterpenoid with a new carbon skeleton from the leaves of Psidium guajava. Organic Letters. 2016, 18, 168-171

2.    Chuang- Jun Li, Jing Fu, Jing-Zhi Yang, Dong-Ming Zhang*, Yu-He Yuan, Nai-Hong Chen.Three triterpenoid saponins from the roots of Polygala japonica Houtt. Fitoterapia. 2012, 83,1184–1190

3.    Chuang-Jun Li, Jing-Zhi Yang, Shi-Shan Yu, Chun-Yang Zhao, Ying Peng, Xiao-Liang Wang, Dong-Ming Zhang*. Glomexanthones A-C, three xanthonolignoid C-glycosides from Polygala glomerata Lour. Fitoterapia. 2014, 93,175–181

4.    Chuang-Jun Li, Ling Yuan, Teng-Fei Ji, Jian-Bo Yang, Ai-Guo Wang, Ya-Lun Su*. Furostanol saponins from the seeds of Allium cepa L. Fitoterapia. 2014, 99:56–63

5.    Chuang-Jun Li, Fu-Gui Xie, Jing-Zhi Yang, Yong-Ming Luo, Xiao-Guang Chen, Dong-Ming Zhang*. Two sesquiterpene pyridine alkaloids and a triterpenoid saponin from the root barks of Tripterygium hypoglaucum. Journal of Asian Natural Products Research 2012, 14(10): 973-980

6.    Chuang-Jun Li, Li Li, Wang Chao, Yang Jing-Zhi, Ye Fei, Tian Jin-Ying, Si Yi-Kang, Zhang Dong-Ming*. A New Ursane-Type Nor-Triterpenoid from the Leaves of Eucommia ulmoides Oliv. Molecules. 2012, 17:13960-13968.

7.    Chuang-Jun Li, Dong-Ming Zhang*, Shi-Shan Yu. Wei Xue, Yu-He Yuan, Nai-Hong Chen. Triterpenoid Saponins and Oligosaccharides from the Roots of Polygala tenuifolia Willd. Chin. J. Nat. Med. 2011, 9 (5): 0321-0328.

8.    Chuang-Jun Li, Jing-Zhi Yang, Shi-Shan Yu, Nai-Hong Chen, Wei Xue, Jing-Feng Hu, Dong-Ming Zhang*. Triterpenoid saponins with Neuroprotective effects from the roots of Polygala tenuifolia Willd. Planta Meidica 2008, 74, 133-141

9.    Chuang-Jun Li, Dong-Ming Zhang*, Shi-Shan Yu. Benzophenone C-glucosides from Polygala glomerata Lour. Journal of Asian Natural Products Research 2008, 10 (3-4), 329-336.

10.  Chuang-Jun Li, Dong-Ming Zhang*, Yong-Ming Luo*, Shi-Shan Yu. Bis-sesquiterpenes and Diterpenes from Chloranthus henryi. Phytochemistry 2008, 69 (16), 2867-2874,

11.  Hang Liu, Chuang-Jun Li, Jing-Zhi Yang, Na Ning, Yi-Kang Si, Li Li, Nai-Hong Chen, Qing Zhao, Dong-Ming Zhang*. Carbazole Alkaloids from the Stems of Clausenalansium. Journal of Natural Products. 2012, 75:677−682.

12.  Jian Zhou, Chuang-Jun Li, Jing-Zhi Yang, Jie Ma, Yan Li, Xiu-Qi Bao, Xiao-Guang Chen, Dan Zhang, Dong-Ming Zhang*Lupane Triterpenoids from the Stems of Euonymus carnosus. Journal of Natural Products 2014, 77, 276-284

13.  Hong-Min Xia, Chuang-Jun Li, Jing-Zhi Yang, Jie Ma, Xiao-Guang Chen, Dan Zhang, Li Li, Dong-Ming Zhang* A,D- seco-Limonoids from the Stems of Clausena emarginata. Journal of Natural Products 2014, 77, 784-791

14.  Hui-Zheng Fu, Chuang-Jun Li, Jing-Zhi Yang, Zhu-Fang Shen, Dong-Ming Zhang*. Potential Anti-inflammatory Constituents of the Stems of Gordoniachrysandr. Journal of Natural Products 2011, 74, 1066-1072.

15.  Chao Wang, Chuang-Jun Li, Jing-Zhi Yang, Jie Ma, Xiao-Guang Chen, Qi Hou, Dong-Ming Zhang*. Anti-inflammatory Sesquiterpene Derivatives from the Leaves of Tripterygium wilfordii. Jorunal of Natural Products, 2013, 76, 85-90

16.  Jing Shi, Chuang-Jun Li, Jing-Zhi Yang, Yu-He Yuan, Nai-Hong Chen, Dong-Ming Zhang*. Coumarin Glycosides and Iridoid Glucosides with Neuroprotective Effects from Hydrangea paniculata. Planta Medica. 2012, 78:1844-1850.

17.  Chao Wang, Chuang-Jun Li, Jie Ma, Jing-Zhi Yang, Xiao-Guang Chen, Qi Hou, Dong-Ming Zhang*. Bioactive sesquiterpene polyol esters from the leaves of Tripterygium wilfordii. Fitoterapia. 2014, 99:56–63

18.  Chao Wang, Chuang-Jun Li, Jie Ma, Jing-Zhi Yang, Xiao-Guang Chen, Qi Hou, Dong-Ming Zhang*. Bioactive 18(4→3)-abeo-abietanoids Derivatives from the Leaves of Tripterygium Wilfordii. RSC Advances, 2015, 5, 30046–30052.

19.  Jie Liu, Chuang-Jun Li, Lin Ni, Jing-Zhi Yang, Li Li, Cai-xia Zang, Xiu-Qi Bao, Dan Zhang and Dong-Ming Zhang*. Anti-inflammatory alkaloid glycoside and quinolone alkaloid derivates from the stems of Clausena lansium. RSC Advances, 2015, 5, 80553–80560.

20.  Jing Shi, Chuang-Jun Li, Jing-Zhi Yang, Jie Ma, Chao Wang , Jia Tang , Yan Li, Hui Chen, Dong-Ming Zhang*, Hepatoprotective coumarins and secoiridoids from Hydrangea paniculata. Fitoterapia 2014, 96 (6) 138–145

21.  Xu Cao, Chuang- Jun Li, Jing-Zhi Yang, Bai-Xing Wei, Shao-Peng Yuan, Yong-Ming Luo, Qi Hou, Dong-Ming Zhang *. Four new neolignans from the leaves of Tripterygium wilfordii. Fitoterapia. 2012, 83:343–347.

22.  Hong-Min Xia, Chuang-Jun Li, Jing-Zhi Yang, Jie Ma, Li Li, Dan Zhang, Xiu-Qi Bao and Dong-Ming Zhang*. Anti-inflammatory amide alkaloids from the stems of Clausena emarginata, Journal of Asian Natural Products Research, 2014, 16, 971–975.

专利申请：

1.张东明; 杨敬芝; 李创军。人参皂苷Rg1的制备方法. 专利申请号CN201010527369.X

2.张东明; 侯琦; 魏佰兴;王超;袁绍鹏;李创军;白金叶.雷公藤甲素衍生物、其制法和其药物组合物与用途.专利申请号：201210249713.2

3.张东明; 侯琦; 李创军等. 雷公藤叶总萜在制备抗类风湿关节炎药物中的应用.专利申请号：201310204299.8.

4.张东明；陈晓光；王超；郎立伟；李创军等. 雷醇内酯衍生物及其应用.专利申请号：201310463847.9