刘站柱, 博士，研究员，博士生导师，1966年8月出生。
Tel：010-63165253
E-mail：liuzhanzhu@imm.ac.cn
研究方向：生物活性天然产物全合成，新药研究与开发
教育背景：
1983.9－1987.7 北京大学化学系获理学士学位；
1987.9－1990.7 北京大学化学系有机化学专业获理学硕士学位；
1999.9－2002.7 中国医学科学院药物所药物化学专业获理学博士学位
工作经历：
1990.7－1999.8
在河北省药物研究所工作，先后任工程师、高级工程师，课题组长，从事新药研究与开发工作；
1996.8－1997.7
在美国Georgia Institute of Technology化学与生物学院进修，从事可卡因拮抗剂的合成和活性研究；
2002.7－现在
在中国医学科学院药物研究所工作，先后任副研究员、研究员，课题组长；2005年
主要研究工作：
曾长期从事新药的研究与开发工作，主持并完成多项国家及省部级课题，成功开发了全身麻醉药、抗前列腺增生药、抗乳腺癌以及抗癫痫等多种药物；近年来主要从事创新药物的研究与开发工作，以具有强生物活性的天然产物为结构先导物，利用全合成手段，设计、合成具有生物活性的结构类似物，研究其构效关系，以期能够发现具有自主知识产权的新药，目前本课题组承担有国家“十三五”新药创制重大专项、中国医学科学院医学与健康科技创新工程等课题。历年来发表研究论文60余篇，培养研究生20余名。
发表论文：
1. Xuan Pan, Zhanzhu Liu*, Total synthesis and antibacterial activity evaluation of griseofamine A and 16-epi-griseofamine A, Organic Letters, 2019, 21, 2393-2396
2. Xuan Pan, Yantao Ma, Zhanzhu Liu*, A Concise Synthesis of (E)-3-aryl-2,3,4,5-tetrahydro-1H-3-benzazonines by Aryne induced [2,3] Stevens Rearrangement of 1,2,3,4-Tetrahydroisoquinolines, Organic & Biomolecular Chemistry, 2018, 16, 7393-7399
3. Zhaozhu Sun, Tian Zhou, Xuan Pan, Ying Yang, Yi Huan, Zhiyan Xiao, Zhufang Shen*, Zhanzhu Liu*, Design, synthesis and biological evaluation of a series of novel GPR40 agonists containing nitrogen heterocyclic rings, Bioorganic & Medicinal Chemistry Letters, 2018, 28, 3050-3056
4. Enming Du, Xuan Pan, Baohe Guan and Zhanzhu Liu*, Asymmetric synthesis of highly functionalized tyrosine derivatives for the construction of bistetrahydroisoquinoline alkaloids, Tetrahedron Letters, 2018, 59, 3029-3032
5. Xuan Pan, Zhanzhu Liu*, Synthesis of 3-Aryl-3-benzazepines via Aryne [1,2] Stevens Rearrangement of 1,2,3,4-Tetrahydroisoquinolines, Organic Chemistry Frontiers, 2018, 5, 1798-1810
6. Xuan Pan, Lulu Tao, Ming Ji, Xiaoguang Chen, Zhanzhu Liu*, Synthesis and cytotoxicity of novel imidazo[4,5-d]azepine compounds derived from marine natural product ceratamine A, Bioorganic & Medicinal Chemistry Letters, 2018, 28, 866-868
7. Xiangran Lu, Xuan Pan, Ying Yang, Ming Ji, Xiaoguang Chen, Zhiyan Xiao, Zhanzhu Liu*, Synthesis and cytotoxicity of a novel series of saframycin-ecteinascidin analogs containing tetrahydro-β-carboline moieties, European Journal of Medicinal Chemistry, 2017, 135, 260-269
8. Lulu Tao, Xuan Pan**, Ming Ji, Xiaoguang Chen, Zhanzhu Liu*, Efficient synthesis and cytotoxicity of novel microtubule-stabilizing agent ceratamine A analogues, Tetrahedron, 2017, 73, 2159-2171
9. Liang Li, Xuan Pan, Baohe Guan and Zhanzhu Liu*, Stereoselective total synthesis of (±)-parthenolide and (±)-7-epi-parthenolide, Tetrahedron, 2016, 72, 4346-4354
10. Xuan Pan, Yi Huan, Zhufang Shen, Zhanzhu Liu*, Synthesis and biological evaluation of novel tetrahydroisoquinoline-C-aryl glucosides as SGLT2 inhibitors for the treatment of type 2 diabetes, European Journal of Medicinal Chemistry, 2016, 114, 89-100
11. Enming Du, Wenfang Dong, Baohe Guan, Xuan Pan, Zheng Yan, Li Li, Nan Wang and Zhanzhu Liu, Asymmetric total synthesis of three stereoisomers of (–)-Renieramycin G and their cytotoxic activities, Tetrahedron, 2015, 71, 4296-4303
12. Xuan Pan, Zhanzhu Liu*, The preparation of novel chiral auxiliaries SAMIQ/RAMIQ and their application in the asymmetric Michael addition, Tetrahedron, 2014, 70, 4602-4610
13. Qiguo Feng, Lulu Tao, Zhanzhu Liu*, Total Synthesis of Microtubule-Stabilizing Agent Ceratamine A, The Journal of Organic Chemistry, 2013, 78, 12814-12818
14. Ju Guo, Wenfang Dong, Wei Liu, Zheng Yan, Nan Wang, Zhanzhu Liu*, Synthesis and cytotoxicity of 3-aryl acrylic amide derivatives of the simplified saframycin-ecteinascidin skeleton prepared from L-dopa, European Journal of Medicinal Chemistry, 2013, 62, 670-676.
15. Wei Liu, Xiangwei Liao, Wenfang Dong, Zheng Yan, Nan Wang, Zhanzhu Liu*, Total synthesis and cytotoxicity of (-)-jorumycin and its analogues, Tetrahedron, 2012, 68, 2759-2764.
16. Wenfang Dong, Wei Liu, Zheng Yan, Xiangwei Liao, Baohe Guan, Nan Wang, Zhanzhu Liu*, Asymmetric synthesis and cytotoxicity of (–)-saframycin A analogues, European Journal of Medicinal Chemistry, 2012, 49, 239-244
17. Wenfang Dong, Wei Liu, Xiangwei Liao, Baohe Guan, Shizhi Chen, Zhanzhu Liu*, Asymmetric total synthesis of (–)-saframycin A from L-tyrosine, The Journal of Organic Chemistry, 2011, 76, 5363–5368
18. Wei Liu, Wenfang Dong, Xiangwei Liao, Zheng Yan, Baohe Guan, Nan Wang, Zhanzhu Liu* , Synthesis and cytotoxicity of (-)-renieramycin G analogues, Bioorganic & Medicinal Chemistry Letters, 2011, 21, 1419-1421
19. Wei Liu, Wen Fang Dong, Xiang Wei Liao, Bao He Guan, Zhan Zhu Liu*, Synthesis of an Isomer of the Renieramycin Skeleton from L-Tyrosine, Journal of Heterocyclic Chemistry, 2011, 48, 414-418
20. Geng Xu, Zheng Yan, Nan Wang, Zhanzhu Liu*, Synthesis and cytotoxicity of cis-dichloroplatinum (II) complexes of (1S, 3S) - 1, 2, 3, 4-tetrahydroisoquinolines, European Journal of Medicinal Chemistry, 2011, 46, 356-363
21. Ke Wang, Zhan-Zhu Liu*, Synthesis of N-methyl-bisindolylmaleimide amino acid methyl ester conjugates and cytotoxicity study, European Journal of Medicinal Chemistry, 2010, 45, 4175-4179
22. Ke Wang, Xiang-Yan Li, Xiao-Guang Chen, Zhan-Zhu Liu*, Synthesis and antitumor activity of bisindolylmaleimide and amino acid ester conjugates, Journal of Asian Natural Products Research, 2010, 12, 36-42
23. Xiang Wei Liao, Wen Fang Dong, Wei Liu, Bao He Guan, Zhan Zhu Liu*, Total Synthesis of (-)-MY
24. Ke Wang, Zhanzhu Liu*, Synthesis of Arcyriarubin A and Arcyriaflavin A via Cross-coupling of Indolylboronic Acid with Dibromomaleimides, Synthetic Communications, 2010, 40, 144 - 150
25. Xiang Wei Liao, Wei Liu, Wen Fang Dong, Bao He Guan, Shi Zhi Chen, and Zhan Zhu Liu *, Total Synthesis of (-)-Renieramycin G from L-Tyrosine, Tetrahedron, 2009, 65, 5709-5715
