学习经历 2001-2007 中国科学院微生物研究所 博士 1997-2000 大连工业大学 硕士 1993-1997 大连工业大学 学士 工作经历: 2019.07-目前 中国科学院微生物研究所 青年研究组长 青年研究员 2014.02-2019.06 中国科学院微生物研究所 青年研究组长 副研究员 2008.02-2014.01 美国耶鲁大学 博士后 研究方向 1、植物-媒介昆虫-植物病毒三者互作的分子机制 80%的植物病毒通过媒介昆虫进行传播，以水稻-媒介昆虫灰飞虱-水稻条纹病毒（Rice stripe virus, RSV）三者互作为研究体系，课题组解析病毒在媒介昆虫体内突破免疫防御并多重物理屏障，最终水平传播至健康植物或垂直传播至子代昆虫的分子机理，为植物病毒病的防控策略提供理论基础。 2、共生基因组育种 微生物组是高等生物的第二套基因组，在高等生物（如植物）的基因组不发生改变的情况下，通过改变共生微生物的基因组，也能赋予植物新的生物学性状。以水稻-灰飞虱-RSV三者互作为研究体系，课题组探究水稻及灰飞虱共生菌群在RSV传播中的功能，鉴定影响RSV传播的共生菌及稳定共生的微生物，开发基于共生基因组的抗病毒策略。

论文及专利（*共同通讯作者, #共同第一作者) 植物-媒介昆虫-病毒三者互作： Huo Y, Yu YL, Liu Q, Liu D, Zhang MT, Liang JN, Chen XY, Zhang LL* and Fang RX*. (2019) Rice stripe virus hitchhikes the vector insect Vitellogenin ligand-receptor pathway for ovary entry. Philosophical Transactions of the Royal Society B, 374(1767):20180312. Li J#, Zhao W#, Wang W, Zhang LL and Cui F. (2019) Evaluation of Rice stripe virus transmission efficiency by quantification of viral load in the saliva of insect vector. Pest Management Science, 75(7):1979-1985. Huo Y#, Yu YL#, Chen LY, Li Q, Zhang MT, Song ZY, Chen XY, Fang RX* and Zhang LL*. (2018) Insect tissue-specific vitellogenin facilitates transmission of plant virus. PLoS Pathogens, 14(2):e1006909. Chen LY, Zhang YM, Chen XY, Fang RX and Zhang LL. (2018) Identification of the endophytic bacteria selectively enriched in the Camellia sinensis leaf. ACTA Microbiologica Sinica, 58(10):1776-1785. Huo Y, Chen X, Fang R and Zhang L. (2018) Study on the production of vitellogenin and its non-nutritional functions. Biotechnology Bulletin, 34(2):1-6. Huo Y#, Chen LY#, Su L, Wu Y, Chen XY, Fang RX* and Zhang LL*. (2016) Artificial feeding Rice stripe virus enables efficient virus infection of Laodelphax striatellus. Journal of Virological Methods, 235:139-143. Zhang F, Li Q, Chen XY, Huo Y, Guo HY, Song ZY, Cui F, Zhang LL* and Fang RX*. (2016) Roles of the Laodelphax striatellus Down Syndrome cell adhesion molecule in Rice stripe virus infection of its insect vector. Insect Molecular Biology. 25(4):413-421. 张莉莉，陈丽莹，霍岩。使灰飞虱获得水稻条纹病毒的方法及其人工饲料。中国[P]. 201610131539X. 2016-03-09，授权日2018-07-06，授权号CN105746439B。 人及动物-媒介昆虫-病原微生物三者互作： Zhang LL, Zhang Y, Adusumilli S, Liu L, Narasimhan S, Dai JF, Zhao Y and Fikrig E. (2011) Molecular interactions that enable movement of the Lyme disease agent from the tick gut into the hemolymph. PLoS Pathogens, 7(6):e1002079. Zhao Y, Kurscheid S, Zhang Y, Zhang LL, Loeliger K, and Fikrig E. (2012) Enhanced survival of Plasmodium-infected mosquitoes during starvation. PLoS One. 7(7):e40556. Liu L, Dai J, Zhao YO, Narasimhan S, Yang Y, Zhang LL and Fikrig E. (2012) The Ixodes scapularis JAK-STAT pathway regulates tick antimicrobial peptides, thereby controlling the agent of human granulocytic anaplasmosis. Journal of Infectious Diseases. 206(8):1233-1241. Liu L, Narasimhan S, Dai JF, Zhang LL, Cheng G and Fikrig E. (2011) Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands. EMBO Reports, 12(11):1196-203. Dai JF, Narasimhan S, Zhang LL, Liu L, Wang PH and Fikrig E. (2010) Tick histamine release factor is critical for Ixodes scapularis engorgement and transmission of the Lyme disease agent. PLoS Pathogens, 6(11):e1001205. 植物-病原微生物互作： Liu D, Bai JY, Fang RX and Zhang LL. (2019) Full genome sequence of Chinese date mosaic-associated virus, a new member of the genus Emaravirus. Acta microbiologica Sinica, accepted. Wang L, Zhang LL, Geng YF, Xi W, Fang RX and Jia YT. (2011) XerR, a negative regulator of XccR in Xanthomonas campestris pv. campestris, relieves its repressor function in planta. Cell Research, 21:1131-1142. Zhang LL, Jia YT, Wang L, Fang RX. (2007) A proline iminopeptidase gene upregulated in planta by a LuxR homologue is essential for pathogenicity of Xanthomonas campestris pv. campestris. Molecular Microbiology, 65:121-136. 微生物组： 张莉莉, 陈丽莹. V5V6区引物解析植物内生细菌菌群的方法.中国[P]. 201910552031.0. 2019-06-24。 张莉莉, 陈丽莹. 一种解析植物内生细菌菌群的方法. 中国[P]. 201711057190.0. 2017-11-01。 张莉莉, 陈丽莹. 一种解析水稻叶际内生细菌菌群结构的方法. 中国[P]. 201710187212.9. 2017-03-27。