主要成就
近年来，先后主持和参与国家自然科学基金、科技成果转化基金、国家“重大新药创制”专项、973项目分题等各类课题14项。主持获批科研项目经费530万元。在Blood、J Infect Dis、Oncogene、Cell Death Dis、J Immunol、Autophagy等国际知名期刊发表SCI论文20余篇。其中以第一或通讯作者发表SCI论著19篇，单篇最高影响因子15.13，IF>5的JCR1区（Q1区）论著6篇。单篇最高引用次数196次，累计引用次数1120次。获得国家发明专利授权4项，获得“重庆市优秀博士论文”。
在药学专业课程《生物技术制药》的教学方面，积累了丰富的教学经验。2015年指导本科生获得第八届“全国大学生药苑论坛”一等奖。参编专著或教材2部。
承担的代表性科研课题：
1)国家自然科学基金，81872392，新发现的环状RNA (Circ-TNPO3)具有竞争结合miR-199a-5p与HuR蛋白的双重功能及其在抑制胃癌转移中的作用机制研究，2019/01-2022/12，57万元，在研，主持。
2)国家自然科学基金，81202310，miR-491通过调控T细胞的增殖和凋亡在诱导T细胞衰竭中的作用机制研究，2013/01-2015/12，23万元，已结题，主持。
3)原第三军医大学“优青人才库”项目，2017/04-2022/04，100万元。
4)重庆市青年科技人才培养项目，cstc2014kjrc-qnrc10008，microRNAs:调控幽门螺杆菌感染与胃癌的新靶点，2014/12-2017/10，20万元，已结题，主持。
5)第三军医大学科技成果转化基金，2014XZH02，血浆microRNAs作为新型分子标志物在局灶节段性肾小球硬化（FSGS）早期诊断和疗效评价中的应用，2015/01-2017/12，30万元，已结题，主持。
6)第三军医大学科研创新基金，2009XQN20，miR-155在幽门螺杆菌感染中负向调控炎症反应的作用及机制研究，2009/07-2011/06，5万元，已结题，主持。
7)国家自然科学基金青年基金项目，81301729，microRNA-25过表达调节抗增殖蛋白Tob1/BTG2在胃癌发生中的作用机制研究，2014/01-2016/12，23万元，已结题，第二负责人。
8)国家自然科学基金面上项目，81071412，miR-30b在幽门螺杆菌诱导的胃上皮细胞自噬调节与持续性感染发生中的机制研究，2011/01-2013/12，32万元，已结题，参与。
9)973项目分题：幽门螺杆菌微进化的研究 （2009CB522606），2008.09-2012.12，已结题，参与。
10)国家自然科学基金面上项目，30770113，幽门螺杆菌中非编码小RNA的预测、鉴定及其在适应胃酸环境中的基因调控作用研究，2008/01-2010/12，30万元，已结题，第二负责人。
11)国家“重大新药创制”专项：口服重组幽门螺杆菌疫苗III期临床试验及免疫持久研究（2008ZX09101-033），2008.11-2010.12，342万元，已结题，参与。
发表的代表性论文
1)Xiao B,Wang Y, Li W, Baker M, Guo J, Corbet K, Tsalik EL, Li QJ, Palmer SM, Woods CW, Li Z, Chao NJ*, He YW*. Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease.Blood.2013, 122(19):3365-75.（IF2018=15.13, JCR 1区）
2)Wang L, Yu T, Li W, Li M, Zuo Q, Zou Q,Xiao B*.The miR-29c-KIAA1199 axis regulates gastric cancer migration by binding with WBP11 and PTP4A3.Oncogene.2019 Jan 9. doi: 10.1038/s41388-018-0642-0.（IF=6.854，JCR1区）
3)Xiao B#,Liu Z#, Li BS, Tang B, Li W, Guo G, Shi Y, Wang F, Wu Y, Tong WD, Guo H, Mao XH, Zou QM*. Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response.J Infect Dis. 2009, 200(6): 916–25.（IF=5.865，JCR 1区）(美国感染疾病协会的官方杂志，单篇引用196次)
4)Xiao B#, *,Wang L#, Li W, Gong L, Yu T, Zuo QF,Zhao HW*,Zou QM*.Plasma microRNA panel is a novel biomarker for focal segmental glomerulosclerosis and associated with podocyte apoptosis.Cell Death Dis. 2018.May 10;9(5):533. doi: 10.1038/s41419-018-0569-y.(IF=5.638，JCR1区)
5)Yu T, Wang L,Li W,Zuo QF,Li MM，Zou QM,Xiao B*.Downregulation of miR-491-5p promotes gastric cancer metastasis by regulating SNAIL and FGFR4.Cancer Sci.2018 May;109(5):1393-1403.（IF=4.372，JCR 2区)
6)Wang N, Wang L, Yang Y, Gong L,Xiao B*（并列通讯作者),Liu X*.A serum exosomal microRNA panel as a potential biomarker test for gastric cancer.Biochem Biophys Res Commun. 2017 Nov 25;493(3):1322-1328.（IF=2.47）
7)Yu T, Zuo QF, Gong L, Wang LN, Zou QM,Xiao B*. MicroRNA-491 regulates the proliferation and apoptosis of CD8(+) T cells.Sci Rep. 2016, 6:30923.（IF=4.26）
8)Zuo QF#, Zhang R#, Li BS, Zhao YL, Zhuang Y, Yu T, Gong L, Li S,Xiao B*（并列通讯作者), Zou QM*. MicroRNA-141 inhibits tumor growth and metastasis in gastric cancer by directly targeting transcriptional co-activator with PDZ-binding motif, TAZ.Cell Death Dis. 2015, 6:e1623.（IF=5.378, JCR1区）
9)Zuo QF#, Cao LY#, Yu T, Gong L, Wang LN, Zhao YL,Xiao B*（并列通讯作者), Zou QM*. MicroRNA-22 inhibits tumor growth and metastasis in gastric cancer by directly targeting MMP14 and Snail.Cell Death Dis. 2015 , 6:e2000.（IF=5.378, JCR1区）
10)Li BS#, Zuo QF#, Zhao YL, Xiao B, Zhuang Y, Mao XH, Wu C, Yang SM, Zeng H, Zou QM*, Guo G*. MicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1 and correlates with poor survival.Oncogene. 2015, 34(20):2556-65.（IF=7.932, JCR 1区）
11)Zhu ED, Li N, Li BS, Li W, Zhang WJ, Mao XH, Guo G, Zou QM*,Xiao B*.miR-30b, Down-Regulated in Gastric Cancer, Promotes Apoptosis and Suppresses Tumor Growth by Targeting Plasminogen Activator Inhibitor-1.PLoS One. 2014, 9(8):e106049.（IF=3.232）
12)Xiao B#, Zhu ED#, Li N, Lu DS, Li W, Li BS, Zhao YL, Mao XH, Guo G, Yu PW*, Zou QM*. Increased miR-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis.Oncol Rep. 2012, 27(2):559-66.（IF=2.297）
13)Li BS#, Zhao YL#, Guo G, Li W, Zhu ED, Luo X, Mao XH, Zou QM, Yu PW, Zuo QF, Li N, Tang B, Liu KY*,Xiao B*(通讯作者).Plasma microRNAs, miR-223, miR-21 and miR-218, as Novel Potential Biomarkers for Gastric Cancer Detection.PLoS One. 2012;7(7):e41629(IF=3.73)
14)Li N, Tang B, Zhu ED, Li BS, Zhuang Y, Yu S, Lu DS, Zou QM,Xiao B*（并列通讯作者), Mao XH*.Increased miR-222 in H. pylori-associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK.FEBS Lett. 2012, 586(6):722-8（IF=3.582, JCR 2区）
15)Li N, Xu X,Xiao B*（并列通讯作者）, Zhu ED, Li BS, Liu Z, Tang B, Zou QM, Liang HP*, Mao XH*. H. pylori related proinflammatory cytokines contribute to the induction of miR-146a in human gastric epithelial cells.Mol Biol Rep. 2012, 39(4):4655-61.（IF=2.506）
16)Xiao B, Li W, Guo G, Li BS, Liu Z, Tang B, Mao XH*, Zou QM*. Screening and identification of natural antisense transcripts in Helicobacter pylori by a novel approach based on RNase I protection assay.Mol Biol Rep. 2009, 36(7):1853-8.（IF=2.506）
17)Xiao B, Li W, Yang J, Guo G, Mao XH, Zou QM*. RGD-IL-24, A Novel Tumor-Targeted Fusion Cytokine: Expression, Purification and Functional Evaluation.Mol Biotechnol. 2009, 41(2):138-44.（IF=2.171）
18)Xiao B, Li W, Guo G, Li BS, Liu Z, Jia KR, Guo Y, Mao XH*, Zou QM*. Identification of small non-coding RNAs in Helicobacter pylori by a bioinformatics based approach.Curr Microbiol. 2009, 58(3):258-63.（IF=1.815）
19)Tang B#,Xiao B#(并列第一作者), Liu Z, Li N, Zhu ED, Li BS, Xie QH, Zhuang Y, Zou QM*, Mao XH*. Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation.FEBS Lett, 2010, 584(8): 1481-1486.（IF=3.582, JCR 2区）
20)Liu Z#,Xiao B#(并列第一作者),Tang B, Li B, Li N, Zhu E, Guo G, Gu J, Zhuang Y, Liu X, Ding H, Zhao X, Guo H, Mao X, Zou Q*. Up-regulated microRNA-146a negatively modulate Helicobacter pylori-induced inflammatory response in human gastric epithelial cells.Microbes Infect. 2010, 12(11): 854-863.（IF=3.101）
21)Tang B#, Li N#, Gu J, Zhuang Y, Li Q, Wang HG, Fang Y, Yu B, Zhang JY, Xie QH, Chen L, Jiang XJ,Xiao B, Zou QM*, Mao XH*. Compromised autophagy by miR-30b benefits the intracellular survival of Helicobacter pylori.Autophagy, 8(7):1045-57, 2012.(IF=12.042,JCR 1区)
22)Shi Y#, Liu XF#, Zhuang Y,Zhang JY, Liu T, Yin Z, Wu C, Mao XH, Jia KR, Wang FJ, Guo H, Flavell RA, Zhao Z, Liu KY,Xiao B, Guo Y, Zhang WJ, Zhou WY, Guo G*, Zou QM*. Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth and contribute to pathology in mice.J Immunol, 184(9):5121-9, 2010.(IF=5.788,JCR 1区)
