主要成就
学术论文(Publications, First/Corresponding Authors):
2019
27.Ye He, Qing Qu, Tiantian Luo, Yuhua Gong, Zongkun Hou, Jia Deng, Yingqian Xu,* Bochu Wang*. Shilei Hao *. Human hair keratin hydrogels alleviate rebleeding after intracerebral hemorrhage in a rat model. ACS Biomaterials Science & Engineering. 2019; 5:2,1113-1122.
26. Tingwang Guo, Xin Yang, Jia Deng, Liancai Zhu*., Bochu Wang*. Shilei Hao *. Keratin nanoparticles-coating electrospin PVA nanofibers for potential neural tissue application. Journal of Materials Science: Materials in Medicine. 2019; 30 (1): 9.
25. Wenfeng Li, Feiyan Gao, Jinlan Kan, Jia Deng*, Bochu Wang*, Shilei Hao *. Synthesis and fabrication of a keratin-conjugated insulin hydrogel for the enhancement of wound. Colloids and Surfaces B: Biointerfaces, 2019; 175:436-444.
2018
24. Tingwang Guo, Peng Ren, Xiaofei Li, Tiantian Luo, Yuhua Gong, Shilei Hao *， Bochu Wang*. Neural injuries induced by hydrostatic pressure associated with mass effecy after intracerebralhemorrhage. Scientific Reports. 2018; 8: 9195.
23. Chongjun Cheng, Xiaoliang Chen, Dongliang Zhai, Feiyan Gao, Guo Tingwang, Wenfeng Li, Shilei Hao *，Jingou Ji *,Bochu Wang*. Development of keratin nanoparticles for controlled gastric mucoadhesion and drug release. Journal of Nanobiotechnology, 2018; 16:24.
22. Guo Tingwang1, Wenfeng Li1, Ju Wang, Tiantian Luo, Deshuai Lou, Bochu Wang*, Shilei Hao *. Recombinant human hair keratin proteins for halting bleeding. Artificial Cells, Nanomedicine and Biotechnology, 2018; 46:S2. 456-461.
2017
21. Luo Tiantian, Guo Tingwang, Yang Qian, Shilei Hao *, Ju Wang, Zhongjun Cheng, Qing Qu, Ye He, Yuhua Gong, Feiyan Gao, Wenfeng Li, Haijian Xia, Bochu Wang*. In Situ Hydrogels Enhancing Postoperative Functional Recovery by Reducing Iron Overload after Intracerebral Haemorrhage. International Journal of Pharmaceutics, 2017; 534: 179-189.
20. Shilei Hao *, Bochu Wang*. Review on Intracerebral Haemorrhage: Multidisciplinary Approaches to the Injury Mechanism Analysis and Therapeutic Strategies. Current Pharmaceutical Design.2017; 23: 2159-2160.
19. Tiantian Luo1, Ju Wang1, Shilei Hao *, Tingwang Guo, Peng Ren, Zhongjun Cheng, Feiyan Gao, Yuhua Gong, Bochu Wang*. Brain Drug Delivery Systems for the Stroke intervention and recovery.Current Pharmaceutical Design.2017; 23: 2161-2176.
18. Tingwang Guo, Peng Ren, Shilei Hao *, Bochu Wang,∗. The underestimated role of mechanical stimuli in brain diseases and the related in vitro models.Current Pharmaceutical Design.2017; 23: 2258-2267.
17. Ju Wang, Shilei Hao *, Tiantian Luo, Zhongjun Cheng, Wenfeng Li, Feiyan Gao, Tingwang Guo, Yuhua Gong, Bochu Wang,∗. Feather keratin hydrogel for wound repair: Preparation, healing effect and biocompatibility evaluation.Colloids and Surfaces B: Biointerfaces, 2017, 149: 341-350 （ESI Highly Cited Papers）.
16. Ju Wang, Shilei Hao *, Tiantian Luo, Tao Zhou, Xin Yang, Bochu Wang * Keratose/poly (vinyl alcohol) blended nanofibers: Fabrication and biocompatibility assessment. Materials Science and Engineering C 72 (2017) 212–219
2016
15. Tiantian Luo,Shilei Hao *,Xiaoliang Chen, Ju Wang , Qian Yang , Yazhou Wang , Bochu Wang*. Development and assessment of kerateine nanoparticles for use as a hemostatic agent.Materials Science and Engineering C.2016. 61: 352-358.
14. Wang Ju, Hao Shilei*, Luo Tiantian, Yang Qian, Wang Bochu *. Development of feather keratin nanoparticles and investigation of their hemostatic efficacy.Materials Science and Engineering C.2016, 68: 768-773.
2015
13. Hao Shilei,Wang Bochu *, Wang Yazhou. Density-dependent gastroretentive microparticles motion in human gastric emptying studied using computer simulation.European Journal of pharmaceutical science.2015; 70: 72-81
12. Hao Shilei,Wang Bochu *, Wang Yazhou. Researching the dose ratio in a controlled release multiple-drug delivery system: using combination therapy with porous microparticles for the treatment of Helicobacter pylori infection.Journal of Materials Chemistry B. 2015;3(3):417-31.
11. Hao Shilei, Wang Bochu *, Wang Yazhou. Porous hydrophilic core/hydrophobic shell nanoparticles for particle size and drug release control.Materials Science and Engineering: C. 2015;49:51-57.
2014
10. Hao Shilei,Wang Yazhou, Wang Bochu *. Sinking-magnetic Microparticles Prepared by Electrospray Method for Enhanced Gastric Antimicrobial Delivery.Molecular Pharmaceutics. 2014;11(5):1640-50.
9. Hao Shilei,Wang Yazhou, Wang Bochu *, Zou Quanming, Zeng Hao, Chen Xiaoliang, Liu Xi, Liu Junyu, Yu Songke. A novel gastroretentive porous microparticle for anti-Helicobacter pylori therapy: Preparation, in vitro and in vivo evaluation.International Journal of Pharmaceutics.2014;463(1):10-21.
8. Hao Shilei,Wang Yazhou, Wang Bochu *, Deng Jia, Zhu Liancai, Cao Yang. Formulation of porous poly (lactic-co-glycolic acid) microparticles by electrospray deposition method for controlled drug release.Materials Science and Engineering: C. 2014;39:113-9.
7. Hao Shilei,Wang Bochu *, Wang Yazhou, Xu Yingqian. Enteric-coated sustained-release nanoparticles by coaxial electrospray: preparation, characterization, and in vitro evaluation.Journal of Nanoparticle Research.2014;16(2):1-11.
2013
6. Hao Shilei,Wang Yazhou, Wang Bochu *, Deng Jia, Liu Xi, Liu Junyu. Rapid preparation of pH-sensitive polymeric nanoparticle with high loading capacity using electrospray for oral drug delivery.Materials Science and Engineering: C.2013;33(8):4562-7.
5. Hao Shilei,Wang Bochu *, Wang Yazhou, Zhu Liancai, Wang Bin, Guo Tingwang. Preparation of Eudragit L 100-55 enteric nanoparticles by a novel emulsion diffusion method.Colloids and Surfaces B: Biointerfaces.2013;108(1):127-33.
2012
4.Ji Jingou *,Hao Shilei,Dong Jin, Wu Danjun, Yang Bin, Xu Yi. Preparation, evaluation, and in vitro release study of O‐carboxymethyl chitosan nanoparticles loaded with gentamicin and salicylic acid.Journal of Applied Polymer Science. 2012;123(3):1684-9.
2011
3. Jingou Ji *,Shilei Hao,Weiqi Liu, Danjun Wu, Tengfei Wang, Yi Xu. Preparation, characterization of hydrophilic and hydrophobic drug in combine loaded chitosan/cyclodextrin nanoparticles and in vitro release study.Colloids and Surfaces B: Biointerfaces. 2011;83(1):103-7.
2. Ji Jingou *,Hao Shilei,Wu Danjun, Huang Rui, Xu Yi. Preparation, characterization and in vitro release of chitosan nanoparticles loaded with gentamicin and salicylic acid.Carbohydrate Polymers.2011;85(4):803-8.
1. Ji Jingou *,Hao Shilei,Liu Weiqi, Zhang Jingfen, Wu Danjun, Xu Yi. Preparation and evaluation of O-carboxymethyl chitosan/cyclodextrin nanoparticles as hydrophobic drug delivery carriers.Polymer Bulletin.2011;67(7):1201-13.
研究项目(Projects)
2017 国家自然科学基金青年项目，具有干预脑出血术后铁超载和再出血功能的新型脑植入剂构建及其止血机制研究（31600770）主持
2016 国家自然科学基金面上项目，应力作用下三磷酸腺苷双磷酸酶的调节拟南芥根系生长发育 （11572063）主研
2015 中央高校基本科研业务费专项项目，个性化超早期治疗脑出血的多功能植入剂研发（106112015CDJXY230002）主持
2015 横向项目，基于小分子蛋白产品咨询及研究，主研
2014 国家重点基础研究计划（“973”）项目，脑出血后血肿应力对豆纹动脉神经复合体结构与功能的影响及其机制研究 （2014CB541603）主研
