主要成就
已发表的部分论文:
Lin Z, Gao W, Hu H, Ma K, Wang J, Zhang X, and Zhang Q*. (2014). Novel thermo-sensitive hydrogel system with paclitaxel nanocrystals: High drug-loading, sustained drug release and extended local retention guaranteeing better efficacy and lower toxicity. Journal of Controlled Release 174, 161-170. (被ESI评为“Highly Cited Papers”)
Lin Z, Mei D, Chen M, Dai W, Yin Y*, Dong A*, and Zhang Q*. A comparative study of thermo-sensitive hydrogels with water-insoluble paclitaxel in molecule, nanocrystal and microcrystal dispersions. (2015). Nanoscale 7, 14838-14847. (被选为Inside Back Cover)
Ma Y#, Lin Z# (co-first author), Fallon J,Zhao Q, Liu D, Wang Y, Liu F (2015). New mouse xenograft model modulated by tumor-associated fibroblasts for human multi-drug resistance in cancer. Oncology Reports 2015.11.01,34(5):2699~2705
Mei D, Lin Z, Fu J, He B, Gao W, Ma L, and Zhang Q*. (2015). The use of alpha-conotoxin ImI to actualize the targeted delivery of paclitaxel micelles to alpha7 nAChR-overexpressing breast cancer. Biomaterials 42:52-65.
Hu H, Lin Z, He B, Dai W, Wang X, Wang J, and Zhang Q*. (2015). A novel localized co-delivery system with lapatinib microparticles and paclitaxel nanoparticles in a peritumorally injectable in situ hydrogel. Journal of Controlled Release 220, 189-200.
Lin Z, Xu S, Gao W, Hu H, Chen M, Dong A*, Yin Y*, and Zhang Q*.(2016). A comparative investigation between paclitaxel nanoparticle- and nanocrystal-loaded thermosensitive PECT hydrogels for peri-tumoural administration. Nanoscale 8, 18782-18791.
Li Y, Zhao T, Wang C, Lin Z, Huang G, Sumer B, and Gao J*. (2016). Molecular basis of cooperativity in pH-triggered supramolecular self-assembly. Nature Communications 7(13214): 1-9
Zhao T, Huang G, Li Y, Yang S, Ramezani S, Lin Z, Baran S, and Gao J*. (2016). A Transistor-like pH Nanoprobe for Tumour Detection and Image-guided Surgery. Nature Biomedical Engineering 1(0006): 1-8.
Gao W,Yang X,Lin Z,He B,Mei D,Wang D,Zhang H,Zhang H,Dai W,Wang X,Zhang Q*. (2017).The use of electronic-neutral penetrating peptides cyclosporin A to deliver pro-apoptotic peptide: A possibly better choice than positively charged TAT. Journal of Controlled Release 261: 174-186
张强, 代文兵, 林志强, 王学清. 难溶性药物凝胶组合物及其制备方法. 专利号: CN2013100091330, 公开号: CN103054794A, 授权日期: 2016-05-25.(已转化实施)