主要成就
研究简介
分子影像是近年来发展十分迅速的一个交叉学科,它是应用影像学方法,对活体状态下的生物过程进行细胞和分子水平的定性和定量研究,涉及生物学、基础医学、临床医学、化学、物理学、药学等多个学科,具有无创、实时、动态、特异等特点,被美国医学会评为未来最具有发展潜力的十个医学科学前沿领域之一。分子探针的研究是分子影像领域的核心,本课题组针对疾病特别是肿瘤在不同发展阶段的特异性标志物设计构建分子探针,在完成临床前动物显像的基础上进行临床转化研究,进行疾病的早期诊断、分期、预后、疗效评价以及个体化治疗。
代表性论文
1. Li L, Wu Y, Wang Z, Jia B, Hu Z, Dong C*, Wang F*. SPECT/CT Imaging of the Novel HER2-targeted Peptide Probe 99mTc-HYNIC-H6Fin Breast Cancer Mouse Models, J Nucl Med.2017 Jan 19. pii: jnumed.116.183863. doi: 10.2967/jnumed.116.183863. [Epub ahead of print]
2. Yu X, Wu Y, Liu H, Gao L, Sun X, Zhang C, Shi J, Zhao H, Jia B, Liu Z, Wang F*. Small-Animal SPECT/CT of the Progression and Recovery of Rat Liver Fibrosis by Using an Integrin alphavbeta3-targeting Radiotracer. Radiology, 2016.5.01, 279(2):502~512.
3. Liu Z*, Liu H, Ma T, Sun X, Shi J, Jia B, Sun Y, Zhan J, Zhang H, Zhu Z, Wang F*. Integrin αvβ6-targeted SPECT imaging for pancreatic cancer detection. J Nucl Med. 2014, 55(6):989-994.
4. Liu Z*, Sun X, Liu H, Ma T, Shi J, Jia B, Zhao H, Wang F*. Early Assessment of Tumor Response to Gefitinib Treatment by Noninvasive Optical Imaging of Tumor Vascular Endothelial Growth Factor Expression in Animal Models. J Nucl Med. 2014, 55(5):818-23.
5. Shi J, Fan D, Dong C, Liu H, Jia B, Zhao H, Jin X, Liu Z, Li F, Wang F*. Anti-tumor Effect of Integrin Targeted 177Lu-3PRGD2 and Combined Therapy with Endostar. Theranostics. 2014, 4(3):256-266.
6. Zhu Z, Weibing Miao W, Li Q, Dai H, Ma Q, Wang F, Yang A, Jia B, Jing X, Sha L, Shi J, Liu Z, Zhao Z, Wang F*, Li F*. 99mTc-3PRGD2 for Integrin Receptor Imaging of Lung Cancer: a Multi-Center Study. J Nucl Med. 2012, 53(5):716-722.
7. Liu Z, Liu Y, Jia B, Zhao H, Jin X, Li F, Chen X, Wang F*. Epidermal Growth Factor Receptor–Targeted Radioimmunotherapy of Human Head and Neck Cancer Xenografts Using 90Y-Labeled Fully Human Antibody Panitumumab. Mol Cancer Ther. 2010, 9(8):2297-2308.
发明专利
1. 一种用于胃癌诊断的药物及其制备方法(王凡,贾兵,杨志),ZL200610088963.7
2. 一种用于胃癌治疗的药物及其制备方法(王凡,贾兵,杨志),ZL200610088962.2
3. 一种RGD多肽放射性药物及其制备方法(王凡,贾兵,史继云),ZL200810239036.X
4. 一种用于胃癌诊断的药物及其制备方法(王凡,贾兵,杨志),ZL200910176734.4
5. 用于integrin αvβ3阳性肿瘤的RGD多肽放射性药物及其制备方法(王凡,史继云,贾兵),ZL200910077039.2
6. 一种靶向整合素αvβ6的多肽放射性药物及其制备方法(王凡,刘昭飞,贾兵,史继云,董诚岩,赵慧云),ZL2014100840659
7. 一种新型VQ多肽放射性药物及其制备方法(王凡,史继云,贾兵,刘昭飞,赵慧云),ZL201310304250.X
8. 一种双靶点放射性分子探针及其制备方法(王凡,刘昭飞,贾兵,史继云,董诚岩,赵慧云),ZL201410084837.9