主要成就
{"awards": "
", "lunzhu": "
¨ Xia, Shanghua; Gan, Lu; Wang, Kailiang; Li, Zheng; Ma, Dawei*.Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides under Mild Conditions. J. Am. Chem. Soc., 2016, 138, 13493？13496.¨ Nomme, Julian#; Li, Zheng #; Gipson, Raymond M.; Wang, Jue; Armijo, Amanda L.; Le, Thuc; Poddar, Soumya; Smith, Tony; Santarsiero, Bernard D.; Nguyen, Hien-Anh; Czernin, Johannes; Alexandrova, Anastassia; Jung, Michael E.; Caius G. Radu,* and Arnon Lavie*. Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability. J. Med. Chem. 2014, 57, 9480-9494.¨ Nathanson, David A.; Armijo, Amanda L.; Tom, Michelle; Li, Zheng; Austin, Wayne R.; Nomme, Julian; Campbell, Dean O.; Dimitrova, Elizabeth; Lee, Jason T.; Ta, Lisa; Darvish, Ryan; Gordin, Ari; Wei, Liu; Liao, Hsiang-I; Wilks, Moses; Martin, Colette; Tsoi, Jennifer; Hong, Aayoung; Sadeghi, Saman; Murphy, Jennifer M.; Boulo, Nidal; Phelps, Michael E.; Faull, Kym F.; Herschman, Harvey R.; Jung, Michael E.; Czernin, Johannes; Lavie, Arnon; and Radu, Caius G. *. Co-Targeting of convergent, switchable nucleotide biosynthetic pathways induces synthetic lethality in leukemia. J. Exp. Med., 2014, 211, 473-486.¨ Murphy, Jennifer M.; Armijo, Amanda L.; Nomme, Julian; Lee, Chi Hang; Smith, Quentin A.; Li, Zheng; Campbell, Dean O.; Liao, Hsiang-I; Nathanson, David A.; Austin, Wayne R.; Lee, Jason T.; Darvish, Ryan; Wei, Liu; Wang, Jue; Su, Ying; Damoiseaux, Robert; Sadeghi, Saman; Phelps, Michael E.; Herschman, Harvey R.; Czernin, Johannes; Alexandrova, Anastassia N.; Jung, Michael E.; Lavie, Arnon*; and Radu, Caius G.* Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J. Med. Chem., 2013, 56, 6696-6708.¨ Deng, Gang; Huang, Zuo-gang; Zhao, Xiao-long; Li, Zheng; Li, Yuan-chao; Jiang, Biao*. Stereospecific Synthesis of Drospirenone. Chinese Journal of Chemistry, 2013, 31, 15-17.¨ Zhou, Zhao-Li; Luo, Zhi-Guo; Yu, Bing; Jiang, Yi; Dai, Mei; Tong, Lin-Jiang; Li, Zheng; Li, Yuan-Chao; Ding, Jian; Miao, Ze-Hong*. Increased accumulation of hypoxia-inducible factor-1alpha with reduced transcription activity mediates the antitumor effect of triptolide. Molecular Cancer, 2010, 9, 268.¨ Yang, Ya-Xi; Li, Zheng; Feng, Hui-Jin; Chen, Guo-Rong; Li, Yuan-Chao*. Concise synthesis of ？ve-membered ring carbasugars based on key ring-closing metathesis. Tetrahedron Letters, 2010, 51, 3848-3851.¨ Li, Zheng; Zhou, Zhao-Li; Miao, Ze-Hong; Lin, Li-Ping; Feng, Hui-Jin; Tong, Lin-Jiang; Ding, Jian*, and Li, Yuan-Chao*. Design, synthesis, and antitumor evaluation of novel triptolide derivatives as potential anticancer agents. J. Med. Chem., 2009, 52, 5115-5123.¨ Li, Zheng; Li, Yuan-Chao*. Structural diversity and structure-activity relationship - new drug research and development of Tripterygium wilfordii Hook.f. Progress in Chemistry, 2009, 21, 2483-2491.¨ Li, Zheng; Deng, Gang; Li, Yuan-Chao*. ZnI2/Et3SiH: A novel mild reduction system for direct deoxygenation of aryl aldehydes, ketones, and α,β-unsaturated enones. Synlett, 2008, 3053.¨ Deng, Gang; Li, Zheng; Peng, Shu-Ying; Fang, Li; Li, Yuan-Chao*. A new route to stereoselective construction of 6, 7-methylene unit from androst-5-en-7-one. Tetrahedron, 2007, 63(22), 4630-4635.
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