主要成就
{"awards": "
2017：中国化学会青年化学奖。 2013：上海市科技启明星计划。 2011：第四届亚太核磁共振会议青年科学家旅行资助奖（口头报告）。 2010：香港科学会年度生命科学领域青年科学家奖，决赛选手； 香港科技大学生命科学部研究生科研奖； 香港大学生物化学研究生学术研讨会平台报告奖。 2009：香港科技大学生物化学系研究生科研成就奖；第三届亚太核磁共振会议青年科学家旅行资助奖。 2005：上海市优秀本科毕业生；复旦大学人民一等奖学金。 2004：复旦大学联合利华一等奖学金；复旦大学优秀学生干部。 2003：复旦大学翔鹭一等奖学金；复旦大学优秀团员。 2002：复旦大学人民一等奖学金；复旦大学三好学生。
", "lunzhu": "
1. Li F, Xu D, Wang Y, Zhou Z, Liu J, Hu S, Gong Y, Yuan J, Pan L.* " Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation " Autophagy. 2018 (online)2. Liu J, Wang Y, Gong Y, Fu T, Hu S, Zhou Z, Pan L.* "Structural Insights into SHARPIN-mediated Activation of HOIP for the Linear Ubiquitin Chain Assembly" Cell Reports. 2017, 21(1):27-36.3. Wei R, Xu L, Liu J, Li Y, Zhang P, Shan B, Lu X, Qian L, Wu Z, Dong K, Zhu H, Pan L, Yuan J*, Pan H*. “SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination” Genes. Dev. 2017, 31, 1162-1176.4. Xu D, Liu J, Fu T, Shan B, Qian L, Pan L*, Yuan J.* “USP25 Regulates Wnt Signaling by Controlling the Stability of Tankyrases” Genes. Dev. 2017, 31, 1024-1035.5. Zhang Z, Gong YK, Zhou Q, Hu Y, Ma HM, Chen YS, Igarashi Y, Pan L*, Tang GL.* “Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade” PNAS. 2017, 114, 1554-1559.6. Li F, Xie X, Wang Y, Liu J, Cheng X, Guo Y, Gong Y, Hu S, Pan L.* "Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins" Nature Communications. 2016, 7:12708.7. Cheng X, Wang Y, Gong Y, Li F, Guo Y, Hu S, Liu J, Pan L.* "Structural Basis of FYCO1 and MAP1LC3A Interaction Reveals a Novel Binding Mode for Atg8 Family Proteins" Autophagy. 2016, 12, 1330-1339.8. Zheng Q, Guo Y, Yang L, Zhao Z, Wu Z, Zhang H, Liu J, Cheng X, Wu J, Yang H, Jiang H, Pan L,* and Liu W.* "Enzyme-Dependent [4+2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4" Cell Chemical Biology. 2016, 23, 352-360.9. Xu D, Shan B, Lee B, Zhu K, Zhang T, Sun H, Liu M, Shi L, Liang W, Qian L, Xiao J, Wang L, Pan L, Finley D, Yuan J.* "Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system" eLife. 2015, 4: e10510.10.Xie X, Li F, Wang Y, Wang Y, Lin Z, Cheng X, Liu J, Chen C, Pan L.* "Molecular Basis of Ubiquitin Recognition by Autophagy Receptor CALCOCO2" Autophagy. 2015, 10, 1775-1789.11.Xia H, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff1 J, Ofengeim D, Zhu H, Wu K, Cai Y, Yates JR, Zhu Z, Yuan J*, Vakifahmetoglu-Norberg H "Degradation of HK2 by Chaperone-Mediated Autophagy promotes Metabolic Catastrophe and Cell Death" J Cell Biol. 2015, 210, 705-716.12.Gong Y, Pan L.* "Recent advances in bioorthogonal reactions for site-specific protein labeling and engineering" Tetrahedron Letters. 2015, 56, 2123-2132 (invited Digest)13.Yan B, Han P, Pan L, Lu W, Xiong J, Zhang M, Zhang W, Li L, Wen Z.* "IL-1β and reactive oxygen species differentially regulate neutrophil directional migration and Basal random motility in a zebrafish injury-induced inflammation model" J Immunol. 2014, 192, 5998-6008.14.Piccoli G, Onofri F, Cirnaru MD, Kaiser CJ, Jagtap P, Kastenmüller A, Pischedda F, Marte A, von Zweydorf F, Vogt A, Giesert F, Pan L, Antonucci F, Kiel C, Zhang M, Weinkauf S, Sattler M, Sala C, Matteoli M, Ueffing M, Gloeckner CJ.* "Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain" Mol. Cell. Bio. 2014, 34, 2147-2161.15.Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J. * "Chaperone-mediated autophagy degrades mutant p53" Genes. Dev. 2013, 27, 1718-1730.16.Yu C, Luo J, Wu J, Pan L, Feng W, Zhang M.* "Membrane-induced lever arm expansion allows myosin VI to walk with large and variable step sizes" J. Biol. Chem. 2012, 287, 35021-35035.17.Wu L#, Pan L#, Zhang C, Zhang M.* "Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereocilia" J. Biol. Chem. 2012, 287, 33460-33471. (#:co-first authors)18.Li X, He L, Che KH, Funderburk SF, Pan L, Pan N, Zhang M, Yue Z.*, Zhao Y.* "Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG" Nature Communications, 2012, 3:662.19.Pan L, Zhang M.* "Structures of Usher Syndrome 1 Proteins and Their Complexes" Physiology, 2012, 27, 25-42. (invited review, cover story)20.Pan L#, Chen J#, Yu J#, Yu H, Zhang M.* "The Structure of the PDZ3-SH3-GuK Tandem of ZO-1 Suggests a Supramodular Organization of the MAGUK Family Scaffold Protein Core" J. Biol. Chem. 2011, 286, 40069-40074. (#: co-first authors)21.Wei Z, Yan J, Lu Q, Pan L, Zhang M.* "Cargo Recognition Mechanism of Myosin X Revealed by the Structure of its Tail MyTH4-FERM Tandem in Complex with the DCC P3 Domain" PNAS. 2011, 108, 3572-3577.22.Feng W, Pan L, Zhang M.* "Combination of NMR spectroscopy and X-ray crystallography offers unique advantages for elucidation of the structural basis of protein complex assembly" Sci.China.Life.Sci. 2011, 54, 101-111. (invited review)23.Wu L#, Pan L#, Wei Z, Zhang M.* "Structure of MyTH4-FERM Domains in Myosin VIIa Tail Bound to Cargo" Science. 2011, 331, 757-760. (#:co-first authors, highlighted by Faculty of 1000, F1000 Cell Biology and F1000 Genomics & Genetics)24.Diao Y, Liu W, Wong CC, Wang X, Lee K, Cheung PY, Pan L, Xu T, Han J, Yates JR 3rd, Zhang M, Wu Z.* "Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding" PNAS. 2010, 107, 20974-2097925.Conan K Wang, Pan L, Chen J, Zhang M.* "Extensions of PDZ domains as important structural and functional elements" PROTEIN & CELL. 2010, 8, 737-751. (invited review)26.Shi Y, Yu J, Jia Y, Pan L, Shen C, Xia J, Zhang M.* "Redox-regulated lipid membrane binding of the PICK1 PDZ domain" Biochemistry. 2010, 49, 4432-44327.Yan J#, Pan L#, Chen X, Wu L, Zhang M.* "The Structure of the Harmonin/Sans Complex Reveals an Unexpected Interaction Mode of the Two Usher Syndrome Proteins" PNAS. 2010,107, 4040-4045. (#: co-first authors)28.Wen W, Yu J, Pan L, Wei Z, Weng J, Wang W, Yan S, Tran T, Hong W, Zhang M.* "Lipid-induced Conformational Switch Controls Fusion Activity of Longin Domain SNARE Ykt6" Mol. Cell. 2010, 37, 383-395.29.Pan L#, Yan J#, Wu L, Zhang M.* "Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23" PNAS. 2009, 106, 5575-5580. (#: co-first authors)30.Chen J#, Pan L#, Wei Z, Zhao Y, Zhang M.* "Domain Swapped Dimerization of ZO-1 PDZ2 Generates Specific and Regulatory Connexin43 Binding Sites" EMBO J, 2008, 27, 2113-2123. (#: co-first authors)31. Pan L#, Wu H#, Shen C#, Shi Y, Jin W, Xia J, Zhang M.* "Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes" EMBO J, 2007, 26, 4576-4587. (#: co-first authors)
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